Pharmacokinetic-pharmacodynamic modeling of the postoperative pain sensation during patient-controlled analgesia with target-controlled infusion of Hydromorphone, taking into account the interaction with intraoperatively administered Sufentanil for elective cardiac surgery - PkPd Hydromorphon-Sufentanil

niversitätsklinikum Erlangen0 个研究点开始时间: 2011年8月18日最近更新: 2012年12月17日

适应症

试验速览

暂无简介。

•Written informed consent
•Ability to understand the nature of patient-controlled analgesia and other study-specific procedures
•Elective cardiac surgery with thoracotomy and subsequent stay in the intensive care unit
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•Use of MAO inhibitors in the last 14 days
•Chronic alcoholism or drug addiction in medical history
•Severe obstuctive or restrictive pulmonal disorders in medical history
•Severe hepatic and renal disorders in medical history
•Hypothyroidism, prostate hyperplasia, pancreatitis, biliary or renal colic in medical history
•Pregnant or nursing females

发起方

niversitätsklinikum Erlangen