Two-week Study to Determine and Compare the Tolerance and Irritation Potential of Clindamycin and Benzoyl Peroxide to Dapsone Gel Topical Acne Medications
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Skin Erythema (Redness)
研究概览
简要总结
This is a randomized, half-face study. On 1 side of the face, the subject will apply 1 of the 2 test products, clindamycin and benzoyl peroxide or dapsone gel and the contra lateral side of the face will remain non-treated to serve as a control.
详细描述
This is a single-blind (blinded expert grader), parallel group, randomized, half-face study being conducted at one clinical site. On 1 side of the face, the subject will apply 1 of the 2 test products, clindamycin and benzoyl peroxide or dapsone gel and the contra lateral side of the face will remain non-treated to serve as a control. Approximately 25-30 male and female healthy subjects without facial acne, aged 18 to 45, will be randomly assigned to each product.
The eligible subjects who qualify will be entered into a 2-week treatment phase. The first of application of the study medication will be supervised at the site, Monday through Friday of each week. Any additional applications should be applied by the subjects at home each evening and the times of application recorded on a diary card. Subjects will apply the study product at home on Saturdays and Sundays and record the times of application on a diary card.
A blinded expert grader will rate comparative product tolerance during the study before study product is applied.
Instrumentation measurements of TEWL will be utilized to evaluate product mildness.
Duplicate sebum samples will be taken from the left and right forehead areas and assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Capable of understanding and willing to provide signed and dated written voluntary informed consent (and any local or national authorization requirements) before any protocol specific procedures are performed.
- •Male and female subjects aged from 18 to 45 years at time of consent.
- •Has a Fitzpatrick Skin Type of I, II, or III.
- •Is willing to discontinue use of all facial products (other than the cleanser provided and makeup or razor and facial shave product) on the face for the 3 days before their baseline/day 0 visit and use only the provided facial products and their normal makeup or razor and facial shaving product for the duration of the study.
- •Is willing to not change brands of makeup or razor and facial shave product during the study.
- •Is willing to refrain from using any facial product on the face other than study products and their normal makeup or razor and facial shave product for the duration of the study.
- •Is willing to refrain from exercising prior to their instrument appointments.
- •Is willing to refrain from showering or drinking caffeinated beverages within 1 hour prior to their instrument visits.
- •Is willing to report to the site for each visit with a clean face and no makeup.
- •Is willing to avoid sunburn, tanning, tanning beds or other excessive sun exposure. Understands that if their skin tone changes significantly during the study it will be necessary to discontinue their participation.
- •Able to complete the study and to comply with study instructions.
- •Sexually active females of childbearing potential participating in the study must agree to use a medically acceptable method of contraception while receiving protocol-assigned product. A woman of childbearing potential is defined as one who is biologically capable of becoming pregnant; including perimenopausal women who are less than 2 years from their last menses.
排除标准
- •Female subjects who are pregnant, trying to become pregnant, or breast feeding.
- •Male subjects that have facial beards (mustache and/or goatee is acceptable).
- •Is a Type I diabetic.
- •Has active or chronic skin allergies.
- •Has a history of acute or chronic disease that might interfere with, or increase the risk of study participation.
- •Has participated in other facial studies in the preceding 30 days or other clinical studies in preceding 14 days.
- •Had skin cancer treatment in preceding 12 months.
- •Has damaged skin on facial areas (eg, from sunburn, tattoos, scars).
- •Had any medical procedure (e.g., laser resurfacing, chemical peels, plastic surgery) to facial areas in preceding 12 months.
- •Had any cosmetic procedure (e.g., microdermabrasion, etc.) to facial areas within 8 weeks of the baseline visit.
- •Use of topical retinoids or related agents for the treatment of acne or photoaging in the preceding 6 months.
- •Live in the same household as currently enrolled subjects.
- •Employees of investigator/clinical research organization (CRO) or Stiefel Laboratories involved in the study, or an immediate family member (partner, offspring, parents, siblings or sibling's offspring) of an employee involved in the study.
- •Any other condition or factor the investigator or his duly assigned representative believes may affect the skin response or the interpretation of the test results.
研究组 & 干预措施
Clindamycin/BPO gel
Once-daily applications of clindamycin/BPO gel to the randomized side of the face either left or right.
干预措施: clindamycin and benzoyl peroxide (Drug)
Dapsone gel
Twice-daily applications of dapsone gel to one side of the face.
干预措施: Dapsone gel (Drug)
结局指标
主要结局
Skin Erythema (Redness)
时间窗: 2 Weeks
Assessment of erythema as part of an evaluation of tolerance of two treatments: clindamycin and benzoyl peroxide or dapsone gel. This was done by visual assessment by an independent blinded grader using the grading scale shown below. Grade Description 0 None 2 Mild erythema 4 Moderate confluent erythema 6 Marked erythema with some edema 8 Marked erythema, edema, possible erosion
Skin Dryness
时间窗: Baseline, Day 1through Day 14
The amount of dryness on the left and right cheek of each panelist. The scale used to evaluate skin dryness is: Grade Description 0 None 2 Slight flaking 4 Moderate flaking/scaling 6 Marked scaling / slight fissuring 8 Severe scaling, fissuring Expert Grader assessments of dryness were taken prior to product application on Days 0, 1, 2, 3, 6, 7, 8, 9, 10, 13 and 14.
次要结局
- Transepidermal Water Loss (TEWL)(2 Weeks)
- Sebum Measurements(2 weeks)
- Skin Hydration(2 weeks)