CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- a Descriptive Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Tidal volume
研究概览
简要总结
The aim with this descriptive multicenter study is to examine the quality of the ventilation given by Emergency Medical Service (EMS) personnel during cardiopulmonary resuscitation (CPR).
Primary endpoint is the ventilation quality measured as ventilation frequency, tidal volume and minute ventilation.
This will primarily be studied during CPR with a 30 compression/2 ventilation ratio performed by the EMS personnel where the airway is managed with a supraglottic device but also in CPR with continuous ventilation (8-10 breaths/minute) after the airway management have been replaced with an endotracheal within the emergency room.
The inclusion of patients will be performed at two sites (Uppsala; Sweden and Utrecht; Holland), all out-of-hospital cardia arrest (OHCA) patients will receive care according to current CPR guidelines using mechanical chest compressions.
详细描述
The inclusion is estimated to run over a two-year period to reach the goal of at least 200 patients. The study has been preceded by a trial period in an effort to solve any logistic and technical problems.
The study will be a prospective descriptive multicenter study where measurement of ventilation data will be sampled during CPR by EMS treating patients with OHCA. Any results from standard laboratory tests related to ventilation quality will be retracted from the patient medical journal systems. In addition to ventilatory variables measured as endpoints, secondary endpoints will also be outcome measures as any ROSC, survival and neurological outcome (mRS, GOS-E) measured at 30 days and at 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Out-of-hospital cardiac arrest (OHCA) treated with CPR performed by the EMS personnel
排除标准
- •Patient age < 18 years
- •Known pregnancy
- •Trauma related cardiac arrest (inc. hanging)
结局指标
主要结局
Tidal volume
时间窗: From start of CPR to end of CPR.
Measured as milliliters per ventilation.
Minute Ventilation
时间窗: From start of CPR to end of CPR.
Measured as litres per minute.
Ventilation frequency
时间窗: From start of CPR to end of CPR.
Measured as ventilations per minute.
次要结局
- Survival rate(6 months post cardiac arrest)
- Variation of etCO2 in relation to different ratios of compression to ventilations(From start of CPR to end of CPR.)
- Neurological outcome(6 months post cardiac arrest.)
- Fraction of dead space ventilation(From start of CPR to end of CPR..)
- Peak inspiratory pressure during ventilation(From start of CPR to end of CPR.)
- Time of inspiration(From start to end of CPR.)
研究者
Sten Rubertsson
Professor
Uppsala University