Combined Low-Dose Isotretenion and Long-Pulsed 1064 ND-YAG Laser in the Treatment of Acne Erythema
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- The degree of acne erythema was determined on the 4-point grading of acne erythema
研究概览
简要总结
Acne erythema consists of telangiectasia and erythematous papules, without a comedo, which occurs as a result of inflammatory acne. Moreover, although acne erythema is common in acne patients, no satisfactory medical or surgical treatment is available for this condition. Some acne erythema lesions may improve with time, but the persistent acne erythema, which is experienced by most patients, is cosmetically unacceptable and leads to frustration and psychological distress.
详细描述
Up to the present time, there have been several studies on the clinical efficacy of different laser modalities for acne treatment. Pulsed dye laser (PDL), 585 or 595 nm, has been demonstrated as one of the effective treatment options Another laser long-pulsed neodymium: yttrium-aluminum-garnet (Nd:YAG) laser with 1064 nm has been commonly used for skin rejuvenation. Nevertheless, the efficacy of this laser for acne treatment has been shown in some studies and case reports. The therapeutic effect on acne lesions is believed to be mediated by the selective photothermolysis of vessels, the upregulation of TGF-β, the reduction of interleukin-8 (IL-8) and Toll-like receptors-2 (TLR-2), and the thermal destruction of sebaceous glands.
Isotretinoin remains the mainstay of acne treatment. No doubt, the side effects of this effective drug holds physicians back from jumping to prescribe it. Recent data suggested that lower doses (0.25 mg/kg/day) may lead to fewer side effects. and fewer flares. Clearing the use of oral isotretinoin in combination with other procedures has expanded our therapeutic options to obtain better control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult Patients with acne
- •Patients of both sexes.
- •Willing to sign an informed consent
排除标准
- •Patients who were taking concomitant acne medication
- •Patients had a history of topical or systemic therapy use for acne for the past 6 months,
- •Patients with a history of photosensitivity reactions
- •Patients with any renal or hepatic compromise or any preexisting hyperlipidemia.
- •Pregnant females as well as females who intend to become pregnant during treatment
- •Hypertrophic scar or keloid.
- •Active or recurrent herpes simplex.
研究组 & 干预措施
Combined Low-Dose Isotretenion and Long-Pulsed 1064 ND-YAG Laser in the Treatment of Acne Erythema
Selected patients will be treated with low-dose oral isotretinoin (10mg/day) over a period of sessions and six sessions of 1064 ND- YAG laser (Deka motous AY) using 150 J/cm2, 20-25 milliseconds pulse duration, and 5 mm spot size, at 2 weeks' interval.
干预措施: Combined Low-Dose Isotretenion and Long-Pulsed 1064 ND-YAG Laser (Combination Product)
结局指标
主要结局
The degree of acne erythema was determined on the 4-point grading of acne erythema
时间窗: 4 months
0 None Clear 1. Mild Faintly detectable erythema, light pink 2. Moderate Dull red, clearly distinguishable 3. severe Deep/dark red
次要结局
未报告次要终点
研究者
Reham Essam
Lecturer of Dermatology
Zagazig University