JPRN-UMIN000009023已完成未知
Effects of perioperative propofol infusion on energy expenditure, fat metabolism, protein catabolism and clinical courses following esophageal cancer surgery - Comparison of two different anaesthesia/sedation techniques in esophageal cancer surgery : propofol anaesthesia/propofol sedation and sevoflurane anaesthesia/midazolam sedation
Department of Anesthesiology and Critical Care, Hiroshima University Hospital0 个研究点目标入组 20 人开始时间: 2012年10月3日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 20
研究概览
简要总结
Propofol anesthesia and postoperative propofol sedation resulted in a reduced peak postoperative bladder temperature and lower postoperative C-reactive protein levels than sevoflurane anesthesia followed by midazolam sedation. However, propofol infusion did not show significant effect on energy expenditure, fat metabolism, protein catabolism and clinical courses.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 40years-old 至 80years-old(—)
- 性别
- Male
入选标准
- 未提供
排除标准
- •Preoperative exclusion criteria includes the patients who are obese (Body Mass Index > 30), have histories of diabetic mellitus, hyperlipidemia, liver dysfunction, renal dysfunction(Cr > 1.0), high-calorie infusion administration or chemoradiotherapy within 1 month before the day of surgery, or take medications of beta-adrenergic blocking agents, steroid agents or non-steroid anti-inflammatory drugs (NSAIDs). Postoperative exclusion criteria includes the patients who are in need of inspiratory oxygen fraction > 0.6 or positive end-expiratory pressure > 5 cmH2O during mechanical ventilation, dopamine > 3 microgram/kg/min, insulin, diuretic drugs, NSAIDs or beta-adrenergic blocking agents during intensive care unit stay.
研究者
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