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临床试验/JPRN-UMIN000009023
JPRN-UMIN000009023已完成未知

Effects of perioperative propofol infusion on energy expenditure, fat metabolism, protein catabolism and clinical courses following esophageal cancer surgery - Comparison of two different anaesthesia/sedation techniques in esophageal cancer surgery : propofol anaesthesia/propofol sedation and sevoflurane anaesthesia/midazolam sedation

Department of Anesthesiology and Critical Care, Hiroshima University Hospital0 个研究点目标入组 20 人开始时间: 2012年10月3日最近更新:
适应症

试验速览

阶段
未知
状态
已完成
发起方
入组人数
20

研究概览

简要总结

Propofol anesthesia and postoperative propofol sedation resulted in a reduced peak postoperative bladder temperature and lower postoperative C-reactive protein levels than sevoflurane anesthesia followed by midazolam sedation. However, propofol infusion did not show significant effect on energy expenditure, fat metabolism, protein catabolism and clinical courses.

研究设计

研究类型
Interventional

入排标准

年龄范围
40years-old 至 80years-old(—)
性别
Male

入选标准

  • 未提供

排除标准

  • Preoperative exclusion criteria includes the patients who are obese (Body Mass Index > 30), have histories of diabetic mellitus, hyperlipidemia, liver dysfunction, renal dysfunction(Cr > 1.0), high-calorie infusion administration or chemoradiotherapy within 1 month before the day of surgery, or take medications of beta-adrenergic blocking agents, steroid agents or non-steroid anti-inflammatory drugs (NSAIDs). Postoperative exclusion criteria includes the patients who are in need of inspiratory oxygen fraction > 0.6 or positive end-expiratory pressure > 5 cmH2O during mechanical ventilation, dopamine > 3 microgram/kg/min, insulin, diuretic drugs, NSAIDs or beta-adrenergic blocking agents during intensive care unit stay.

研究者

发起方
Department of Anesthesiology and Critical Care, Hiroshima University Hospital

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