Magnetic resonance guided radiotherapy to the stellate ganglia for ventricular arrhythmia

niversity of Oxford0 个研究点目标入组 13 人开始时间: 2024年6月26日最近更新: 2024年7月8日

适应症

试验速览

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•1.Male or Female, aged at least 18 years old.
•2.Known diagnosis of structural heart disease defined as any patient with impaired left ventricular ejection fraction (less than 55%) due to any cause including; ischaemic cardiomyopathy, dilated cardiomyopathy, hypertrophic cardiomyopathy or Arrhythmogenic cardiomyopathy.
•3.CMR compatible ICD device implanted a minimum of 6 months ago, under follow-up at Oxford University Hospitals NHS Foundation Trust.
•4.Experienced more than one appropriate ICD therapy (shocks or anti-tachycardia pacing) for ventricular arrhythmia in the last 6 months
•5.Established on optimal guideline based medical therapy for heart failure

•General Exclusion Criteria:
•1.Device radiation dose or nearby organs at risk exceeding the limit for low-risk radiotherapy as defined by the UK Consensus and AAPM 2019 guidelines
•2.Female patients who are pregnant, lactating or planning pregnancy during the study period
•3.Patients who are terminally ill, inappropriate for intervention, or unable to consent
•4.Any impediment to communication which, in the opinion of the investigator, might prevent the investigator communicating effectively with the patient during the study which could cause a safety or reliability concern.
•5.Any other condition which, in the opinion of the investigator, might affect the safety of the participant or reduce the reliability of the study results
•6.Involvement in any other research project where the procedures would affect the outcomes of this study.
•Additional Exclusion Criteria for Participants Undergoing MRI Studies:
•7.Metal clips or metallic foreign body
•8.Prior injury to the eye involving fragments of metal
•9.Prior shrapnel injuries
•10.Any other metallic or electronic implants affected by the magnetic field
•11.History of severe claustrophobia
•12.Severe liver damage, TB, pulmonary disease, anaemia, blood coagulation disorders

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