NCT00517426已完成4 期
Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure
Centro Cardiologico Monzino1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2007年7月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Suppression of periodic breathing
研究概览
简要总结
To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure.
Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic heart failure in stable clinical condition
- •exercise-induced periodic breathing
排除标准
- •comorbidities
- •NYHA class IV
研究组 & 干预措施
Active Acetazolamide
Experimental
干预措施: acetazolamide (Drug)
结局指标
主要结局
Suppression of periodic breathing
时间窗: two days
次要结局
- suppression of sleeping apnea(two days)
研究者
Piergiuseppe Agostoni
MD PhD
Centro Cardiologico Monzino
研究点 (1)
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