ISRCTN88315555已完成未知

Cardiometabolic effect of weight loss in metabolically healthy obese subjects (MHO)

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (FIMABIS)0 个研究点目标入组 279 人开始时间: 2016年7月26日最近更新: 2023年8月28日

适应症

试验速览

2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/28682864 results 2018 Other publications in https://pubmed.ncbi.nlm.nih.gov/29434314/ Substudy results (added 18/08/2023) 2019 Results article in https://pubmed.ncbi.nlm.nih.gov/31093012/ (added 18/08/2023)

•1. Aged 35-55 years
•2. Metabolically healthy obese (MHO)*
•3. BMI between 30-45 kg/m2
•*A participant is considered to have MHO status when meeting =1 of these four metabolic syndrome criteria: fasting plasma glucose =100 mg/dL, blood pressure =135/85 mmHg (or use of blood pressure-lowering agents), HDL-cholesterol =50 mg/dL, and triglycerides =150 mg/dL (or use of lipid-lowering therapies).

•1. Diabetes or impaired glucose tolerance
•2. Hypertension
•3. Pregnancy or planning to become pregnant during the study
•4. Cardiovascular disease
•5. Severe systemic disease (advanced organ failure, dementia, cancer)
•6. Immobilized individuals
•7. Alcohol or drug abuse
•8. Severe psychiatric illness
•9. Patients who self-initiated a program of physical activity or started a diet in the past three months
•10. Weight loss =5 kg in the last 6 months of unknown cause

发起方

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (FIMABIS)