Comparison of Motor Skill Acquisition Between Individuals With Neurological Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Peripheral nerve activity
研究概览
简要总结
Stroke survivors frequently show persistent gait deficits in their chronic stages even after years of intensive rehabilitation. This may be caused by diminished capability of re-acquiring motor skills post stroke. Thus, the overall purpose of this research project is to examine stroke survivors' capability of learning a novel leg task over 3 visits, 1-2 weeks apart. The capability of learning a new skill is then correlated with the individual's neurological functions (nerve activity and movement coordination) and her/his gait performance (gait speed, gait symmetry, and force production).
详细描述
The walking after stroke called "hemiparetic gait" is characterized by slow and asymmetrical steps with poor motor control on the paretic leg while paradoxically increasing the cost of energy expenditure. Biomechanical evidence shows that impaired gait performance for people with chronic stroke is not solely the result of the loss of muscle strength, but involves complicated movement discoordination across multiple joints in the affected leg. This has been taken to indicate a persistent motor control deficit in the paretic leg post stroke. Recent imaging studies suggest that the persistent motor control deficit after stroke may be the result of the disruption of motor memory consolidation, a process by which a newly-learned motor skill is transformed from a fragile state to a stable state and is "saved" in our brain afterward. This indicates that the same brain area responsible for controlling motor activity is also involved in memorizing newly-learned skills during the early stage of motor learning. Presence of persistent motor control deficits in the chronic stage may be attributed to the fact that damage to the brain cortex significantly impacts the ability of acquiring motor skills and consequentially defers the improvement of motor function, including gait.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy adults have no ongoing neurological, musculoskeletal issues.
- •Individuals with chronic stroke had medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment.
- •Individuals have multiple sclerosis disease diagnosed by his/her physician
- •MRI or CT evidence from the imaging report shown that the stroke and multiple sclerosis disease primarily involve cortical and subcortical regions.
- •Individuals with chronic stroke have hemiparesis involving the lower extremity.
- •Individuals with chronic stroke or multiple sclerosis have no passive range of motion limitation in bilateral hips and knees. Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less.
- •Visual acuity can be corrected by glasses or contact lens to 20/
- •Able to walk independently with/without assistant devices for 10 meters.
- •Able to maintain standing position without any assistance for more than 30 sec.
- •Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24.
排除标准
- •Pregnant women.
- •MRI or CT evidence of involvement of the basal ganglia or cerebellum, or evidence of any other brain damage or malignant neoplasm or tumors.
- •Have any metal implants, cardiac pacemakers, or history of seizures.
- •Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training.
- •Any vestibular dysfunction or unstable angina.
- •Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia*
结局指标
主要结局
Peripheral nerve activity
时间窗: During the first session of learning visuomotor leg reaching task
A surface electrode will be placed on the calf muscle in one leg. Then a low-intensity of electrical stimulation will be delivered to a nerve behind the knee to trigger the motor responses.
Changes in movement errors
时间窗: During the first session of learning visuomotor leg reaching task, 24-hour after the first session, and 7-days after the first learning learning session
Average movement error will be calculated as the angular deviation of the foot path from a straight line path to the target at the time of peak velocity in each trial.
次要结局
- Walking performance(Before the first session of learning visuomotor leg reaching task)
- Fugl-Meyer Lower Extremity Function Assessment(Before the first session of learning visuomotor leg reaching task)
- Mini-mental State Examination(Before the first session of learning visuomotor leg reaching task)
研究者
Shih-Chiao Tseng
Associate Professor
Texas Woman's University