The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Olfactory Function Test
研究概览
简要总结
To explore the efficacy of olfactory training on olfactory and other non-motor symptoms in PD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PD was diagnosed according to the criteria of Movement Disorders and Parkinson Disease Group of Chinese Society of Neurology of Chinese Medical Association.
- •Olfactory score was 1 standard deviation lower than the corresponding age norm;
- •no medication plan in the past four weeks or no change in medication plan in the past four weeks, which can be maintained until the end of the experiment; 4.40-75 years old, with normal vision, hearing and language understanding and expression ability;
- •5.Good cooperation of patients
排除标准
- •Parkinson's syndrome and Parkinson's plus syndrome caused by cerebrovascular disease, encephalitis, trauma, drugs, etc.;
- •Neuropsychiatric diseases that may affect the sense of smell, such as depression, anxiety, schizophrenia, etc.;
- •History of nasal disease or surgery, such as rhinitis, sinusitis, nasal septum deviation, etc. Upper respiratory tract infection in the past 3 weeks;
- •Long-term smoking and occupations that inhale chemical irritants for a long time.
研究组 & 干预措施
OT grroup
Olfactory training used repeated stimulation of different olfactory substances at high concentrations, combined with odor association and odor identification training, twice in the morning and evening, each time for 5 minutes, for 15 weeks.
干预措施: Olfactory training (Device)
No intervention group
There were only pre-test and post-test without any intervention
结局指标
主要结局
Olfactory Function Test
时间窗: baseline;15 weeks
The olfactory test developed by the Institute of Psychology, Chinese Academy of Sciences was used to evaluate the olfactory ability, including threshold, discrimination, and recognition.
次要结局
- MoCA(baseline;15 weeks)
- Pittsburgh sleep quality index(baseline;15 week)
- HAMA(baseline;15week)
- HAMD(baseline;15 week)
研究者
WANG KAI
Head, Dept of Neurology & Medical Psychology, Director, Cognitive Neuropsychology Lab, PRC
Anhui Medical University