Is the Nerve Growth Factor (NGF) a Useful Biomarker in Neurogenic Bladder Dysfunction After Spinal Cord Injury?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- urinary concentration of nerve growth factor
研究概览
简要总结
Spinal cord injury (SCI) almost always affects bladder function as well. As a result of this bladder dysfunction, individuals with SCI have to undergo regular invasive examination of their bladder function (urodynamic examination).
The nerve growth factor (NGF) is released from smooth muscle cells of the bladder, and there are reports, that the concentration of NGF is elevated in the urine of patients with bladder dysfunction. The NGF concentration can also be measured in the blood. The concentration of NGF in the blood and urine of SCI individuals has not yet been investigated. These concentrations may correlate with the severity of bladder dysfunction, and may thus be used to replace or at least reduce the number of the more invasive urodynamic examinations.
The hypothesis that urine and blood NGF concentrations in individuals with SCI are higher compared to individuals with healthy bladder function will be tested.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •physiologic bladder function
排除标准
- •no signed consent form
- •age <18 / >80 years
- •urinary tract infection
- •bladder surgery
- •radiation therapy of the pelvic area
- •pregnancy
- •bleeding disorder
- •Study Group
- •Inclusion Criteria:
- •neurogenic detrusor overactivity
- •presentation for urodynamic examination
- •Exclusion Criteria:
- •no signed consent form
- •age <18 / >80 years
- •urinary tract infection
- •bladder augmentation
- •bladder evacuation by permanent catheterization
- •radiation therapy of the pelvic area
- •pregnancy
- •bleeding disorder
结局指标
主要结局
urinary concentration of nerve growth factor
时间窗: day 0
次要结局
- urodynamics(day 0)
- demographics(day 0)
- serum concentration of nerve growth factor(day 0)
- International Prostate Symptom Score (I-PSS)(day 0)