Epidemiologic, Clinical and Genetic Profile of Prostate Cancer in Arab Countries
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Identification of single nucleotide polymorphisms (SNPs) in genes associated with prostate cancer in the Qatari population.
研究概览
简要总结
This protocol is designed to collect a small amount of blood and tissue from individuals with prostate cancer for extraction of DNA (genetic material) for the study of the genetic basis of prostate cancer. The study population will include individuals with known prostate cancer and controls without prostate cancer. The study will be conducted in Doha, Qatar at the Hamad Medical Corporation and Weill Cornell Medical College (Qatar). Individuals in the study population will be of Arab descent from Qatar. In this protocol, researchers will survey epidemiologic factors and medical records of patients with prostate cancer in order to study the clinical characteristics of these individuals. The researchers will collect blood and tissue samples to evaluate the genetic characteristics of individuals with prostate cancer. The researchers will also collect blood samples of individuals without prostate cancer to serve as a control. The goal will be to identify genes that are associated with prostate cancer and gene profiles that are associated with differing prognoses in individuals who have prostate cancer.
详细描述
The study population will include individuals with known prostate cancer and controls without prostate cancer. Individuals in the study population will be of Arab descent from Qatar. In this protocol, researchers will survey epidemiologic factors and medical records of patients with prostate cancer in order to study the clinical characteristics of these individuals. The researchers will collect blood and tissue samples to evaluate the genetic characteristics of individuals with prostate cancer. The researchers will also collect blood samples of individuals without prostate cancer to serve as a control. The goal will be to identify genes that are associated with prostate cancer and gene profiles that are associated with differing prognoses in individuals who have prostate cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All study subjects should be able to provide informed consent
- •Males or females ages 40 years or older (see section A8 for the rationale for the inclusion of females)
- •Individuals of Arab descent from Qatari peninsula without any personal or family history of prostate cancer
排除标准
- •Individuals with family history of prostate cancer
- •Individuals not deemed in good overall health by the investigator will not be accepted into the study
- •Inclusion/Exclusion Criteria for Prostate Cohort
- •Inclusion Criteria:
- •All study subjects should be able to provide informed consent
- •Males ages 40 years or older
- •Individuals from the Qatari Peninsula whose ancestors up to three generations back were natives of Qatar.
- •Individuals undergoing Trans Rectal Ultrasound (TRUS) biopsy as dictated by their standard clinical care
- •Ultrasound OR digital rectal examination consistent with prostate disease OR A level of PSA (Prostatic Specific Antigen) greater than 3.0
- •Exclusion Criteria:
- •Patient refuses consent
结局指标
主要结局
Identification of single nucleotide polymorphisms (SNPs) in genes associated with prostate cancer in the Qatari population.
时间窗: 3 years
次要结局
- Use of gene expression profiles to develop molecular signatures of prostate cancer that are associated with clinical/pathological phenotypes (e.g., tumor grade, histology, disease stage, responsiveness to therapy)(3 years)