NCT05160870招募中不适用
Genotype-phenotype Correlation and Pathogenic Mechanism in Hereditary Ataxia
Second Affiliated Hospital, School of Medicine, Zhejiang University1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2021年6月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Serum neurofilament light chain
研究概览
简要总结
The investigators aimed to find appropriate biomarkers such as serum neurofilament light chain in reflecting disease severity in hereditary ataxia from a large cohort during long-term follow-up. The disease severity is indicated by clinical scales and brain MRI tests.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •genetically diagnosed as Spinocerebellar ataxia
排除标准
- •deny follow-yp
结局指标
主要结局
Serum neurofilament light chain
时间窗: from 2021 to 2025
Serum neurofilament light chain levels were collected among patients in preclinical or mild stage of Spinocerebellar ataxia, especially type 3.
次要结局
未报告次要终点
研究者
研究点 (1)
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