The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- Ovarian reserve assessment by measuring AMH level.
研究概览
简要总结
The investigators aimed to investigate the effects of salpingectomy and Methotrexate administration on ovarian reserve in ectopic pregnancy.
详细描述
In this study, the effects of unilateral laparoscopic salpingectomy and single dose of systemic Methotrexate administration on ovarian reserve in patients diagnosed with ectopic pregnancy were investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ectopic pregnancy diagnosis
排除标准
- •history of endometriosis, ovarian surgery, systemic chemotherapy, ART treatment.
- •patients treated with multiple doses of methotrexate or different surgical procedure (salpingostomy, milking)
研究组 & 干预措施
Methotrexate only
Single dose of systemic Methotrexate administered to 55 patients.
干预措施: Methotrexate (Drug)
Salpingectomy only group
Laparoscopic unilateral salpingectomy performed to 61 patients.
干预措施: salpingectomy (Procedure)
Salpingectomy following Methotrexate
15 patients underwent laparoscopic unilateral salpingectomy following unsuccessful single dose of methotrexate administration.
干预措施: Methotrexate (Drug)
Salpingectomy following Methotrexate
15 patients underwent laparoscopic unilateral salpingectomy following unsuccessful single dose of methotrexate administration.
干预措施: salpingectomy (Procedure)
结局指标
主要结局
Ovarian reserve assessment by measuring AMH level.
时间窗: 1-3 months
Ovarian reserve were assessed before and after treatment by measuring AMH levels.
次要结局
- Number of participants with treatment related adverse effect on fertility.(2 years of follow up after treatment)
研究者
Enes Taylan
Medical Doctor, Ob&Gyn Specialist
Ege University