A Micro/Nano Device for Exhaled Breath Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 728
- 试验地点
- 1
- 主要终点
- Detection of disease related markers (biomarkers) from concentrated volatile organic compounds in breath samples
研究概览
简要总结
Use of a microfabricated silicon device to concentrate ultra trace volatile organic compounds (VOCs) in human exhaled breath for quantitative analysis of VOCs.
详细描述
Will use Fourier Transform Mass Spectrometry (FT-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to analyze concentrated VOCs. The purpose of this study is to search for disease-related markers in the breath in subjects with known or suspected lung or other cancer, or pulmonary disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For controlled (healthy) subjects - we are seeking persons who do not have a known history of cancer or pulmonary disease.
- •Both smokers and nonsmokers are invited to participate as control subjects.
- •For experimental subjects, we are seeking persons with pulmonary disease but no known history of cancer, as identified by the investigators during routine clinic or office visits.
- •Additionally for experimental subjects, we are seeking persons with known or suspected lung or other cancers, as identified by the investigators during routine clinic or office visits.
排除标准
- 未提供
结局指标
主要结局
Detection of disease related markers (biomarkers) from concentrated volatile organic compounds in breath samples
时间窗: 1 day (After sample collection)
The concentrated volatile organic compounds in exhaled breath samples will be analyzed by statistical software for search for disease related markers (biomarkers).
次要结局
未报告次要终点
研究者
Xiao-An Fu
Assistant Professor
University of Louisville