Etoricoxib Prescribing Patterns and Adverse Events of Interest During Etoricoxib Treatment in UK Primary Care; an Updated Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 79,189
- 主要终点
- Dose of Initial Etoricoxib Prescription
研究概览
简要总结
This postmarketing study was conducted to describe prescribing patterns for etoricoxib (ARCOXIA®) in General Practice and describe the incidence of selected adverse events recorded in the United Kingdom (UK) Medicines and Health Care Products Regulatory Agency (MHRA) General Practice Research Database (GPRD).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients in the MHRA's Full Feature GPRD (FF-GPRD) who have at least one electronic outpatient prescription record for etoricoxib issued by a General Practitioner during the period (April 1, 2002 to December 31, 2015) at the date of query execution against the FF-GPRD data warehouse.
排除标准
- •Not registered in a GPRD-contributing practice that had continuously
- •collected data deemed to be 'up-to-standard' for research purposes from 1 April 2002 through to 31 December
- •Never registered as a permanent patient of a General Practitioner in the practice
- •Registration details were not acceptable (i.e. incomplete data or logically implausible dates)
- •Not registered with a General Practitioner for at least 365 days before the date that the patient's first etoricoxib prescription was recorded in the GPRD
研究组 & 干预措施
Etoricoxib Prescription (Period 1)
First Etoricoxib Prescription, Apr. 1, 2002 to Feb. 17, 2005
干预措施: Etoricoxib (Drug)
Etoricoxib Prescription (Period 2)
First Etoricoxib Prescription, Feb. 18, 2005 to Dec. 31, 2015
干预措施: Etoricoxib (Drug)
Repeat Etoricoxib Prescription
One prescription during the Period 1 and, at least, one etoricoxib prescription during Period 2.
干预措施: Etoricoxib (Drug)
结局指标
主要结局
Dose of Initial Etoricoxib Prescription
时间窗: At first prescription (during a time period up to 13.75 years)
Duration of Initial Etoricoxib Prescription
时间窗: At first prescription (during a time period up to 13.75 years)
Participant's Baseline Characteristics (Demographics and Medical)
时间窗: At first prescription (during a time period up to 13.75 years)
Incidence of Adverse Events of Special Interest Among Etoricoxib Users
时间窗: During a time period up to 13.75 years
次要结局
- "Off-label" use of Etoricoxib(At first prescription (during a time period up to 13.75 years))