NCT00689598Unknown不适用
Use of Spironolactone to Treat Patients With Paroxysmal Atrial Fibrillation- A Multi-Center, Prospective, Randomized, Placebo-Controlled, Double Blind Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- time to a first electrocardiographically confirmed AF
研究概览
简要总结
To determine whether or not spironolactone can prevent or delay the occurrence of atrial fibrillation.
详细描述
To determine whether or not adding spironolactone can prevent or delay the occurrence of paroxysmal atrial fibrillation in patients who have received propafenone treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
III
Placebo Comparator
Placebo
干预措施: Spironolactone (Drug)
Experimental
Experimental
Drug intervention
干预措施: Spironolactone (Drug)
Experimental
Experimental
Drug intervention
干预措施: Placebo (Drug)
结局指标
主要结局
time to a first electrocardiographically confirmed AF
时间窗: 3 months
次要结局
- 1. Response rate: Improvement of any symptom scores and/or SF36 scores more than 50 % (compared with re-randomization scores) 2. Difference of mean episodes of documented AF between the spironolactone and placebo groups.(3 months)
研究者
研究点 (1)
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