NCT03778944招募中不适用
Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities
Nazmy Edward Seif1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2018年12月20日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Post-operative creatinine clearance
研究概览
简要总结
Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess & compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •end-stage renal disease, for living-donor kidney transplantation
排除标准
- •severe cardiac or hepatic dysfunction
- •coagulopathy
研究组 & 干预措施
C group
Active Comparator
Adequate hydration
干预措施: Adequate hydration (Procedure)
M group
Active Comparator
Mannitol infusion
干预措施: Mannitol infusion (Procedure)
D group
Active Comparator
Dopamine infusion
干预措施: Dopamine infusion (Procedure)
结局指标
主要结局
Post-operative creatinine clearance
时间窗: 7 days
Post-operative creatinine clearance level of the transplanted kidney graft is measured in ml/min
次要结局
未报告次要终点
研究者
Nazmy Edward Seif
Clinical Professor
Cairo University
研究点 (1)
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