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临床试验/NCT07328165
NCT07328165进行中(未招募)不适用

Core Stability vs Respiratory Muscle Training in Children With Down Syndrome

Cairo University1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2026年2月20日最近更新:
干预措施

试验速览

阶段
不适用
状态
进行中(未招募)
入组人数
60
试验地点
1
主要终点
Bone mineral density (BMD) of femoral neck and lumbar spine

研究概览

简要总结

Children with Down syndrome often exhibit diminished physical fitness levels and lower bone mass. Numerous factors contribute to this decrease in bone mass density, including decreased levels of leptin, reduced muscle mass and strength, impaired balance, and skeletal abnormalities. These factors further exacerbate the risk of developing osteoporosis in this population. Therefore, it is crucial to prioritize interventions that focus on maximizing peak bone mass during childhood in order to enhance the quality of life for adults with Down syndrome. The study aims to compare the impact of core stability exercises and respiratory muscle strengthening exercises on bone mineral density in children with Down syndrome. Sixty Children with Down syndrome will be assessed and included in this study. The age of children will range from 10 to 13 years. Children will be allocated randomly into three groups (control and two study group A & B). The control group receives a physical therapy program, study group A receives traditional physical therapy program with core stability exercises, and study group B receives traditional physical therapy program with respiratory muscle strengthening exercises. Groups will be evaluated using dual energy X-ray absorptiometry DXA (DPX-IQ, version 4.6A). Bone mineral density (BMD) of femoral neck and lumbar spine will be determined and the mean density will be expressed as g/cm2.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
10 Years 至 13 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Age will range from 10-13 years
  • Diagnosed with Down syndrome.
  • Children with the ability to understand and follow verbal commands and instructions used during training and tests
  • Able to stand and walk independently

排除标准

  • Any neurological, mobility disorders, vision or hearing loss, cardiac anomalies or musculoskeletal disorder
  • With asthma or any chronic chest diseases
  • With significant tightness or deformities in the lower limbs and limber spine

研究组 & 干预措施

Control Group

Active Comparator

The control group will receive the physical therapy program and conduct three times peer week over 8 consecutive weeks under the supervision of a physical rehabilitation specialist

干预措施: Control /Conventional Physiotherapy Group (Behavioral)

Core Stability Exercise Group

Experimental

This group will receive core stability exercises in addition to physical therapy program as control group.

干预措施: Core Stability Exercise Group (Behavioral)

Respiratory Muscle Strengthening Group

Experimental

This group will receive respiratory muscle strengthening exercises in addition to physical therapy program as control group

干预措施: Respiratory Muscle Strengthening Group (Device)

结局指标

主要结局

Bone mineral density (BMD) of femoral neck and lumbar spine

时间窗: 8 weeks

. Groups will be evaluated using dual energy X-ray absorptiometry DXA (DPX-IQ, version 4.6A).

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Reham Saeed Alsakhawi

Principal Investigator

Cairo University

研究点 (1)

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