Iron Bioavailability of High Surface Area Ferric Phosphate in Thai Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Fractional iron absorption
研究概览
简要总结
The primary objective of this study is to compare iron absorption of high surface area ferric phosphate with that of ferrous sulfate and bulk ferric phosphate in a rice-based meal in non-pregnant women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women of reproductive age (18 to 49 years) in Thailand
- •BMI < 23 kg/m2
- •Body weight < 65 kg
- •Mildly anaemic to normocythemic (Hb 80-110 g/L)
- •Ferritin < 25 µg/L
- •Not pregnant (confirmed by pregnancy test stripe) or lactating
- •No inflammation (CRP < 5 mg/L)
- •Having provided written informed consent
排除标准
- •Haemoglobinopathies (except heterozygosity for haemoglobin E and alpha-thalassemia 1)
- •Coeliac disease or other chronic diseases of malabsorption that could influence iron absorption or metabolism
- •Blood donation or significant blood loss due to surgery or accident < 4 months before start of the study
- •Consumption of vitamin or mineral supplements 2 weeks before start of the study
- •Regular use of medication (except oral contraceptives), that influences iron absorption
- •Chronic inflammatory disease
研究组 & 干预措施
FeSO4 fortified rice test meal
干预措施: FeSO4 fortified rice test meal (Dietary Supplement)
FePO4 fortified rice test meal
干预措施: FePO4 fortified rice test meal (Dietary Supplement)
HiFePO4 1 fortified rice test meal
干预措施: HiFePO4 1 fortified rice test meal (Dietary Supplement)
HiFePO4 2 fortified rice test meal
干预措施: HiFePO4 2 fortified rice test meal (Dietary Supplement)
结局指标
主要结局
Fractional iron absorption
时间窗: Measured 14 days after consumption of the 4 different types of iron vehicles (Days 16 and 31)
Iron absorption will be determined by measurement of the isotopic ratio change from the 4 different types of iron vehicles (FeSO4 fortified rice test meal, FePO4 fortified rice test meal, HiFePO4 1 fortified rice test meal, HiFePO4 2 fortified rice test meal).
次要结局
未报告次要终点
研究者
Prof. Michael B. Zimmermann
Prof. Dr. med.
Swiss Federal Institute of Technology