A COMPARATIVE CLINICAL STUDY ON DHATRYADI KWATHA AND EXTERNAL APPLICATION OF FALGU PATRA SWARASA ALONG WITH VIRECHANA IN THE MANAGEMENT OF SHWITRA W.S.R. TO VITILIGO
试验速览
- 阶段
- 1/2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- ASSESSMENT WILL BE DONE ON THE SPECIALLY DESIGNED PROFORMA OR ASSESSING SIGN AND SYMPTOMS IN SCORING PATTERN
研究概览
简要总结
1. Shwitra characterizedby white patches which effectively resembles and represents Vitiligo accordingto modern science.
2. Most of the patients ofShwitra were more concerned about Shweta Mandala (hypo pigmented or white coloured patches) insteadof any other symptoms of Shwitra and visit hospital for same.
3. Viruddha Ahara(incompatible diet) like milk with salt, milk with sour foods, excess taking offermented foods were observed in most of patients of Shwitra.
4. Virechana, Dhatryadi Kwatha and External application of Phalgu-patra swarasa (Group A) therapy showed betterresults in cardinal symptoms like colour, number, area and size of patches thanDhatryadi Kwatha and External application of Phalgu-patra swarasa (Group B) therapy.
5. Group B showed better effect on Mandalotpatti and Rukshata like symptoms.
6. Group A presented better repigmentationresponse on face, neck, dorsa of hands, elbows and ankles and didn’t respond ondistal extremities and on Sansrishta (mixed one anotherpatches).
7. Virechana group showed betterresult in VASI, VETF and VETI score as compare to Shamana group.
8. Group A exhibited better percentage fractionthan Group B on Quality of life parameters i.e. DLQI, VitiQoL and VIS-22.
9. Results of Group B indicated that effectiveinhibition of the inflammatory response alone might not be sufficient to inducespontaneous repigmentation in Shwitra (Vitiligo).
10. Overall60% patients showed moderate improvement, 33.33% patients showed markedimprovement and 6.67% showed mild improvement in Group A. Overall 66.67%patients showed mild improvement while 33.33% patients showed moderateimprovement in Group B.
11. Therapeutically, both thegroups (Group A- Virechana, Dhatryadi Kwatha and External application) and Group B- Dhatryadi Kwatha and External application) providedconsiderable symptomatic relief. However, Group A (Virechana group) was found to berelatively more effective in the management of majority of the symptoms and onquality of life.
Hence, the null hypothesis is rejected andalternative hypothesis is accepted i.e. “Dhatryadi Kwatha and external application of Phalgu-patra swarasa are more effective along with Virechana in the management of Shwitra (Vitiligo)â€.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients having sign and symptoms of Shwitra (Vitiligo).
- •Patients indicated for Virechana as per Ayurvedic classics.
- •If the patients to withdrawn ongoing medications like systemic corticosteroids, systemic or local photosensitizers or drugs scientifically proven to cause hyperpigmentation on local application or systemic administration will be included.
- •Washout period after quitting will be for 7 days.
排除标准
- •1.Patients having chronic condition, more than 10 years 2.Patients contraindicated for Virechana as per Ayurvedic classics.
- •3.Patients having all other de-pigmentory disorders.
- •4.Patients having serious cardiac, renal, hepatic diseases.
- •5.Patients having major illness like IDDM, NIDDM which are poorly controlled and any other systemic diseases.
- •6.Patches due to burning, chemical explosion etc.
- •7.Located at region of Guhya(Genital region), Panitala(Foot soles and Hand soles), Oshtha (Lips), Aekanga, Sarvanga(whole body).
- •8.Patches with Raktaroma & sansakta.
- •9.Patients with known drug hypersensitivity, photosensitivity, 10.Pregnant and lactating women.
- •11.Patients with ongoing medications like systemic corticosteroids, systemic or local photosensitizers or drugs scientifically proven to cause hyperpigmentation on local application or systemic administration.
结局指标
主要结局
ASSESSMENT WILL BE DONE ON THE SPECIALLY DESIGNED PROFORMA OR ASSESSING SIGN AND SYMPTOMS IN SCORING PATTERN
时间窗: 2 MONTHS
次要结局
- ASSESSMENT WILL BE DONE ON THE SPECIALLY DESIGNED PROFORMA OR ASSESSING SIGN AND SYMPTOMS IN SCORING PATTERN(2 MONTHS)