NCT04014153已完成不适用
The Impact of Comorbidity as a Risk Factor of Acute Kidney Injury (AKI) in Patients With Stable Coronary Artery Disease (CAD)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,023
- 主要终点
- Overall mortality
研究概览
简要总结
Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media.
The aim of the study is to assess the prevalence of contrast-induced AKI in 2012-2013 and 2017 cohorts and to evaluate the potential risk factors of CI-AKI to better guide the prevention in patients of higher risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Informed consent
- •Male and female patients 18 y. o. and older
- •Verified stable coronary artery disease (CAD)
- •Receiving optimal medical treatment and requiring percutaneous coronary intervention (PCI) with iodinated contrast media
排除标准
- •Pregnancy, lactation
- •Conditions affecting the prognosis (kidney failure, liver failure, oncology)
- •Acute coronary syndrome (ACS)
- •Contraindications to PCI
- •Therapy with nephrotoxic drugs during the enrolment which cannot be stopped
- •Refusal to sign the informed consent
结局指标
主要结局
Overall mortality
时间窗: 5 years
Stroke
时间窗: 5 years
CABG
时间窗: 5 years
CABG after PCI at enrolment
GI bleeding
时间窗: 5 years
PCI
时间窗: 5 years
Repeat PCI after the enrolment
Cardiovascular mortality
时间窗: 5 years
Myocardial infarction
时间窗: 5 years
次要结局
未报告次要终点
研究者
Olga Mironova
Principal Investigator
I.M. Sechenov First Moscow State Medical University
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