Cardiac Arrest Incidence and Outcome Among Patient With COVID-19 Pneumonia in French ICUs
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 186
- 试验地点
- 36
- 主要终点
- Incidence of unexpected cardiac arrest
研究概览
简要总结
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19) pandemic. Among COVID-19 complications, in-hospital cardiac arrest (IHCA) was reported with a very poor outcome in a retrospective single-center study (0,7% of 30 days survival with good neurological outcome among IHCA patients with a resuscitation attempt), related to its natural course and management. The incidence of unexpected in-ICU cardiac arrest (ICUCA) due to COVID-19 is still unknown. Additionally, outcome of COVID-19 patients admitted in ICU for an out-of-hospital cardiac arrest (OHCA) is also undescribed.
The objective this study is :
- to report the incidence of ICUCA among patients hospitalized in French ICU for COVID-19.
- to report morbidity and mortality among COVID-19 patients admitted alive in ICU for an OHCA or an IHCA.
The secondary objective is to assess outcome and identify risk factors of ICUCA occurrence among patients admitted for COVID-19.
详细描述
Retrospective and prospective multicentric observational registry in French intensive care units (ICU) including all consecutive adult patients admitted in ICU with a documented SARS-CoV-2 disease :
- For an out-of-hospital or an in-hospital cardiac arrest (OHCA and IHCA respectively)
- Or presenting an unexpected in-ICU cardiac arrest (ICUCA) Patients characteristics, cardiac arrest history and patients outcome will be recorded according to Utstein recommendations.
Patients presenting an expected cardiac arrest in ICU related to withdrawal of life sustaining therapies (WLST) will be excluded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted in intensive care unit with a documented SARS-CoV-2 disease
- •For an out-of-hospital or an in-hospital cardiac arrest
- •Or an in-hospital cardiac arrest
- •Or presenting an unexpected in-intensive care unit cardiac arrest
排除标准
- •Age under 18 y.o
- •Expected in-intensive care unit cardiac arrest related to withdrawal of life sustaining therapies.
- •Withdrawal of patient or next-of-kin informed consent
结局指标
主要结局
Incidence of unexpected cardiac arrest
时间窗: 7 months
Percentage of unexpected in-intensive care unit cardiac arrest among COVID-19 patients admitted to intensive care unit
次要结局
- Charlson score(7 months)
- Etiology retained to explain cardiac arrest occurrence(7 months)
- Modified Rankin score (mRS) at ICU discharge, at hospital discharge and at 3 months(3 months)
- Organ failure score at ICU admission and/or before unexpected in-ICU cardiac arrest(7 months)