Analysis of the Effect of a Diet Enriched With Polyunsaturated Fatty Acids on the Proteomic and Metabolomic Profiles of Blood Plasma of Healthy People Aged 18-50
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Metabolite concentrations in plasma
研究概览
简要总结
Analysis of the effect of dietary intervention based on increased polyunsaturated fatty acid intake on health. Specifically changes in blood lipid profile, as well as proteomic and metabolomic profiles of healthy adults will be analyzed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •good health,
- •proper body weight
- •not meeting the needs for polyunsaturated fatty acids
排除标准
- •increased body weight,
- •limited communication to an extent that makes it impossible to carry out a food interview,
- •eating disorders (according to food history),
- •metabolic diseases,
- •pregnancy,
- •lactation,
- •taking drugs that influence the metabolism of lipids or carbohydrates
研究组 & 干预措施
The high PUFA diet group
This will receive detailed nutritional recommendations and will consume at least 4 table spoons of olive oil or 30 grams of nuts daily for 12 weeks.
干预措施: The high PUFA diet group (Other)
Control group
The Control group will receive general nutritional recommendations based on Human Nutrition Recommendations for Polish Population.
结局指标
主要结局
Metabolite concentrations in plasma
时间窗: 12 weeks
Metabolite concentrations in plasma samples are measured by high resolution mass spectrometry at baseline and after the intervention
Nutrient intake
时间窗: 12 weeks
Nutrient intake (3-day food records)
Proteomic analysis of plasma
时间窗: 12 weeks
The aim is to identify biomarkers in the blood and to determine the differences between people from the control and the intervention group
Concentrations of lipoproteins and glucose
时间窗: 12 weeks
Serum concentrations of lipoproteins and glucose at baseline and after the intervention \[mg/dl\]
次要结局
- Height(12 weeks)
- Waist circumference(12 weeks)
- Body mass(12 weeks)
- Percentage body fat(12 weeks)
- hip circumference(12 weeks)