Hand Grip Strength As a Screening Tool for Respiratory Dysfunction in Huntington's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Maximal Hand grip strength
研究概览
简要总结
Hereditary neurodegenerative diagnosis of Huntington's disease (HD) is associated with a progressive deterioration of the respiratory system function . This fact contributes strongly to the increased risk of aspiration pneumonia as a primary cause of death in people with HD. But regularly objective monitoring of the airway system condition is in common clinical practice almost impossible for high time requirements and the need for specialized expensive devices . This drives the need for a simpler and more cost-effective screening tool. In recent years published studies, working with all ages and genders, show correlation between hand grip strength (HGS) and respiratory parameters. As a second simple screening tool, we chose a short questionnaire called the Index of pulmonary dysfunction.
详细描述
Goal: To identify a simple method for screening respiratory muscle and cough weakness in Huntington's Disease (HD) patients, suitable for clinical practice.
Hypothesis 1: Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow will be significantly correlated with maximal hand grip strength in HD patients.
Hypothesis 2: Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow will be significantly correlated with the Index of pulmonary dysfunction in HD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Genetic confirmed diagnosis of Huntington's disease
排除标准
- •diagnosis of other concomitant neurological diseases;
- •a history of cardiovascular or lung disease;
- •respiratory symptoms such as cough, phlegm, wheezing, or dyspnea at the time of assessment
结局指标
主要结局
Maximal Hand grip strength
时间窗: Up to 35 weeks (once on a single screening visit)
Unit of Measure: kg Assessment followed recommendation of The American Society of Hand Therapists. HSG is measured using DHD-1 digital hand dynamometer (SAEHAN®,Seahan Corporation).
Voluntary peak cough flow
时间窗: Up to 35 weeks (once on a single screening visit)
Unit of measure: l/min Assessments will be performed in accordance with American Thoracic Society/European Thoracic Society guidelines.
Maximal expiratory pressure, Maximal inspiratory pressure
时间窗: Up to 35 weeks (once on a single screening visit)
Unite of measure: cmH2O Assessments will be performed in accordance with American Thoracic Society/European Thoracic Society guidelines.
次要结局
- Index of Pulmonary dysfunction(Up to 35 weeks (once on a single screening visit))
研究者
Romana Konvalinková
physiotherapist of the rehabilitation section in General University Hospital Prague
General University Hospital, Prague