NCT00981825已完成3 期
Efficacy of Salivary Bacteria and Post Brushing
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- CFU (Colony Forming Units)
研究概览
简要总结
Research study to compare the effects of brushing with two commercially available toothpastes on salivary bacteria after brushing
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female volunteers 18-65 years of age
- •Good general health
- •Must sign informed consent form
- •Must discontinue oral hygiene on the mornings of each appointment and between sampling periods.
- •No history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study.
排除标准
- •Medical condition which requires pre-medication prior to dental procedures/visits
- •Medical condition which precludes eating/drinking for 12 hrs.
- •History of allergy to common dentifrice ingredients
- •Subjects unable or unwilling to sign the informed consent form.
- •Moderate or advanced periodontal disease.
- •2 or more decayed untreated dental sites at screening.
- •Other disease of the hard or soft oral tissues.
- •Impaired salivary function (e.g. Sjogren's syndrome or head and neck irradiation).
- •Use of medications that can currently affect salivary flow
- •Current use of antibiotics
- •Use of antibiotics or antimicrobial drugs within 30 days prior to study visit #
- •Pregnant or nursing women.
- •Participation in any other clinical study within 30 days prior to enrollment into this study.
- •Use of tobacco products
- •Subjects who must receive dental treatment during the study dates.
- •Current use of Antibiotics for any purpose.
- •Immune compromised individuals (HIV,AIDS, immuno suppressive drug therapy)
研究组 & 干预措施
A
Placebo Comparator
fluoride toothpaste control
干预措施: Fluoride (Drug)
B
Active Comparator
triclosan/fluoride toothpaste
干预措施: Triclosan/Fluoride (Drug)
结局指标
主要结局
CFU (Colony Forming Units)
时间窗: 4 hours
Total number of salivary bacterial colony forming units (lower number = less colonies present)
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
1 期
The comparative study of salivary fluoride concentration and fluoride retention after toothbrushing with and without rinsing in 6 years old children.Dry tooth brushing with 1500 ppm fluoride toothpaste in 6 year-old childrenchildrendry brushingfluoride retentionfluoride toothpastesalivary fluoride concentrationTCTR20240403005Postgraduate Study and Research Sector18
已完成
不适用
Verification of the effect of oral care wet sheets on oral tracheal intubation patientsJPRN-UMIN000046663Yamaguchi University Hospital56
已完成
3 期
Compare the Clinical Efficacy of Prototype ToothpastesDental PlaqueNCT00926029Colgate Palmolive98
已完成
不适用
Effectiveness of Toothbrushing Techniques in Plaque Removal and Caries Lesion ControlCariesNCT01501357University of Sao Paulo220
尚未招募
1 期
To test saliva and compare anti-caries agents for prevention of radiation caries among Head and Neck cancer patients undergoing radiotherapy.CTRI/2019/03/017977itte Deemed to be University