Development and Internal Validation of a Clinicopathologic Prognostic Model for Overall Survival in Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemoimmunotherapy and Esophagectomy: A Multicenter Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 414
- 试验地点
- 3
- 主要终点
- Overall Survival (OS)
研究概览
简要总结
The goal of this retrospective observational study is to develop and internally evaluate a prognostic model for overall survival in patients with esophageal squamous cell carcinoma who received neoadjuvant chemoimmunotherapy followed by esophagectomy.
Researchers will review existing clinical, pathologic, and follow-up data from 414 patients treated at three medical centers between 2019 and 2025. The study will assess whether routinely available clinicopathologic factors can provide prognostic information beyond postoperative pathologic staging.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 80 years Histologically confirmed esophageal squamous cell carcinoma Received at least 1 cycle of neoadjuvant chemoimmunotherapy before surgery Underwent subsequent esophagectomy
排除标准
- •History of other malignancies Preoperative antitumor therapy other than neoadjuvant chemoimmunotherapy Incomplete clinicopathologic or follow-up data
研究组 & 干预措施
ESCC Cohort After Neoadjuvant Chemoimmunotherapy and Esophagectomy
This cohort includes patients aged 18-80 years with histologically confirmed esophageal squamous cell carcinoma who received at least one cycle of neoadjuvant chemoimmunotherapy followed by esophagectomy. Patients were treated at three participating medical centers between 2019 and 2025.
结局指标
主要结局
Overall Survival (OS)
时间窗: From the date of esophagectomy to death or last follow-up, up to 73 months.
Overall survival is defined as the interval from the date of esophagectomy to death from any cause. Participants alive at last contact are censored on the date of last follow-up.
次要结局
未报告次要终点
研究者
Zhen-Yu Ding
Professor
Sichuan University