Analysis of M1 and M2 subpopulation of macrophages in periodontal health and disease.

Dr Ashish Jain0 个研究点目标入组 44 人开始时间: 待定最近更新: 2021年11月24日

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•Periodontal diagnosis will be based on the periodontal classification of the American Academy of Periodontology (1999) and American Academy of Periodontology Task Force Report on the Update to the 1999 Classification of Periodontal Diseases and Conditions (2015). Each subject will be included in any of the following four groups depending upon his/her clinical condition and treatment requirements as:
•a) Group (1) (Control): 11 age matched patients showing clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets.
•b) Group (2) (Gingivitis) : 11 patients presenting with clinical evidence of gingivitis, such as red color, swelling of the gingival margin and bleeding corresponding to gingival indices 2 and 3 (LÃ¶e and Silness) without bone resorption or periodontal pocketing.
•c) Group (3) (Moderate Periodontitis): 11 patients with 3â??4mm CAL, 5â??7mm pockets, 16% to 30% or >3 mm & <=5 mm radiographic bone loss with presence of bleeding on probing.
•d) Group (4) (Severe Periodontitis): 11 patients with >=5mm CAL, >=7mm pockets, >30% or >5 mm radiographic bone loss with presence of bleeding on probing.

•Patients with the history of:
•1. Pregnancy, lactation, smoking
•2. Any systemic condition that could affect the progression of periodontal disease (e.g., diabetes and immunological disorders)
•3. Long-term administration of anti-inflammatory medication
•4. Excessive consumption of alcohol
•5. Localized radiation therapy of the oral cavity
•6. On any medications or have undergone periodontal therapy within the preceding 6 months

发起方

Dr Ashish Jain