NCT02745522已完成1 期
Can Oxytocin Enhance the Placebo Effect?
University of Electronic Science and Technology of China1 个研究点 分布在 1 个国家目标入组 224 人开始时间: 2015年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 224
- 试验地点
- 1
- 主要终点
- Memory performance in different phases
研究概览
简要总结
The current study aimed to investigate whether oxytocin (OXT) had effect on placebo effect.
详细描述
The current study included three phases to investigate oxytocin effect on placebo effect:
- In a double-blind, between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 66 healthy male subjects using working memory task.
- In a single-blind(subjects were informed that the treatment was oxytocin), between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 53 healthy male subjects using working memory task.They were informed that oxytocin would increase memory perfomance by a female experimenter.
- In a single-blind(subjects were informed that the treatment was oxytocin), between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 53 healthy male subjects using working memory task. But the subjects were told that oxytocin would decrease the performance by the same female experimenter.
- In a single-blind(subjects were informed that the treatment was oxytocin), between-subject, placebo controlled design study to investigate the intranasal OXT (24IU) treatment in 52 healthy male subjects using working memory task. The subjects were told that oxytocin would increase the performance by a male experimenter.
Memory performance was included as dependant factor. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), Interpersonal Trust Scale(ITS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorder
排除标准
- •history of head injury;
- •claustrophobia;
- •medical or psychiatric illness.
研究组 & 干预措施
Placebo
Placebo Comparator
Placebo nasal spray
干预措施: Placebo (Drug)
Oxytocin
Experimental
Oxytocin nasal spray
干预措施: Oxytocin (Drug)
结局指标
主要结局
Memory performance in different phases
时间窗: 1 hour
N-back memory performance (accuracy) was included into analysis.
次要结局
未报告次要终点
研究者
Keith Kendrick
Prof.
University of Electronic Science and Technology of China
研究点 (1)
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