Pathophysiological Explorations of Red Blood Cells
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,750
- 试验地点
- 25
- 主要终点
- Quantification of inflammation in sickle cell disease
研究概览
简要总结
GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of erythropoiesis, red blood cells and iron metabolism, and to develop new therapeutic protocols capable of providing added value in terms of innovation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •To be affected or have a family history of disease bound to the red blood cell,
- •For adult subjects, have signed an informed consent form,
- •For minor or major under legal safeguard subjects, the form must be signed by both parents (for minors) or by the legal representative,
- •Be affiliated to health insurance.
排除标准
- •Being deprived of freedom
研究组 & 干预措施
Affected patients
Biological samples of blood for all patients. Biological samples of saliva, surgical remainder (skin, tumor, kidney,....), saliva, urine, hair.
干预措施: Biological sampling (Other)
Non affected relatives
Biological samples of blood for all relatives.
干预措施: Biological sampling (Other)
结局指标
主要结局
Quantification of inflammation in sickle cell disease
时间窗: 20 years
Activation rate of circulating mastocytes (%)
Correlation between transfusion yield and the storage of red blood cell bags
时间窗: 20 years
Increasing in haemoglobin concentration at 6 hours post transfusion
Quantification of mitochondria removal during erythropoiesis in SDC patients, consequences on the mature RBC
时间窗: 20 years
Mitochondria rate and level of ROS in RBC measured by Flow Cytometry
Efficiency of Phosphodiesterase inhibitor on neutrophil adhesion in Sickle cell disease
时间窗: 20 years
Proportional change in adhesion rate (%) of neutrophils measured in the peripheral blood before and after treatment with phosphodiesterase inhibitors
Innovative markers of spleen fonctionality
时间窗: 20 years
Retention rate (%) of red blood cells using Microsphiltration compared with non affected subjects
Study of iron metabolism in Diamond-Blackfan Anemia patients
时间窗: 20 years
Dosage of iron metabolism parameters
Markers of post-artesunate hemolysis
时间窗: 20 years
Concentration of pitted red blood cells at day 3
次要结局
未报告次要终点