Comparison of Lower Urinary Tract Symptoms, Bowel Function, and Sexual Health Across Menopausal Stages in Women
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Bristol Female Lower Urinary Tract Symptoms (BFLUTS) Score
研究概览
简要总结
The menopausal transition is associated with substantial hormonal alterations that may adversely affect lower urinary tract function, bowel function, and sexual health. Although these symptoms are common, few studies have comprehensively evaluated all three pelvic floor compartments across different menopausal stages.
The aim of this study is to compare lower urinary tract symptoms, bowel symptoms, and female sexual function among women in the perimenopausal, early postmenopausal, and late postmenopausal stages. In addition, the relationship between menopausal stage and symptom severity will be investigated.
详细描述
Menopause is characterized by estrogen deficiency, resulting in structural and functional alterations in pelvic floor tissues. Lower urinary tract symptoms, bowel dysfunction, and female sexual dysfunction are increasingly recognized as important health concerns during the menopausal transition.
Despite growing evidence regarding individual pelvic floor disorders, few studies have simultaneously evaluated urinary, colorectal, and sexual symptoms across different menopausal stages.
This study will classify women according to STRAW+10 criteria into:
Perimenopause Early postmenopause Late postmenopause
Participants will undergo a single assessment session. Demographic information together with validated questionnaires will be collected. No intervention or treatment will be provided.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 40-65 years
- •Intact uterus and at least one ovary
- •Perimenopause or postmenopause according to STRAW+10 criteria
- •Able to read and understand Turkish
排除标准
- •Hormone replacement therapy within the previous 6 months
- •Oral contraceptive use
- •Antipsychotic medication use
- •Previous pelvic surgery
- •Neurological or systemic diseases affecting bladder or bowel function
- •Active urinary tract or vaginal infection
- •Pelvic radiotherapy or chemotherapy history
- •Active gynecological or urological malignancy
- •Alcohol or substance abuse during the previous year
研究组 & 干预措施
Perimenopause
Perimenopausal women according to STRAW+10 criteria
干预措施: Constipation Severity Assessment (Other)
Late postmenopause
Late postmenopausal women according to STRAW+10 criteria
干预措施: Constipation Severity Assessment (Other)
Perimenopause
Perimenopausal women according to STRAW+10 criteria
干预措施: Assessment for Bowel Symptoms (Other)
Perimenopause
Perimenopausal women according to STRAW+10 criteria
干预措施: Sexual Function Assessment (Other)
Early postmenopause
Early postmenopausal women according to STRAW+10 criteria
干预措施: Assessment for Lower Urinary Tract Symptoms (Other)
Perimenopause
Perimenopausal women according to STRAW+10 criteria
干预措施: Assessment for Lower Urinary Tract Symptoms (Other)
Early postmenopause
Early postmenopausal women according to STRAW+10 criteria
干预措施: Assessment for Bowel Symptoms (Other)
Early postmenopause
Early postmenopausal women according to STRAW+10 criteria
干预措施: Constipation Severity Assessment (Other)
Early postmenopause
Early postmenopausal women according to STRAW+10 criteria
干预措施: Sexual Function Assessment (Other)
Late postmenopause
Late postmenopausal women according to STRAW+10 criteria
干预措施: Assessment for Lower Urinary Tract Symptoms (Other)
Late postmenopause
Late postmenopausal women according to STRAW+10 criteria
干预措施: Assessment for Bowel Symptoms (Other)
Late postmenopause
Late postmenopausal women according to STRAW+10 criteria
干预措施: Sexual Function Assessment (Other)
结局指标
主要结局
Bristol Female Lower Urinary Tract Symptoms (BFLUTS) Score
时间窗: Baseline (single assessment)
Lower urinary tract symptoms will be assessed using the validated Bristol Female Lower Urinary Tract Symptoms questionnaire. Higher scores indicate greater symptom severity and poorer urinary health-related quality of life
次要结局
- Colorectal Anal Distress Inventory-8 (CRADI-8)(Baseline (single assessment))
- Cleveland Clinic Constipation Score(Baseline (single assessment))
- Female Sexual Function Index(Baseline (single assessment))
- Bristol Stool Form Scale(Baseline (single assessment))
研究者
Betül Çınar
Associated professor
Bezmialem Vakif University