Comparison of effect of opioid free anaesthesia with conventional opioid based anaesthesia in major spine surgery : A Randomized Comparative trial

This study is to compare the effects of opioid free anaesthesia with conventional opioid based anaesthesia in  patient undergoing to major spine surgery .

Two groups one is opioid based groups in which fentanyl is use as bolus before the induction of general anaesthesia and intravenous infusion of fentanyl will be started during intraoperative period. than all vital parameters  and VAS will be noted .Second groups is opioid free groups in which Dexmedetomidine and lignocaine will be used as bolus and  infusion during the intraoperative periods. And  all  haemodynamic parameters and VAS will be noted. than extubation done .Modified aldrete score will be noted in both the groups. Then total dose of rescue analgesia requirement will be noted upto the 48 hours in spine surgery. In rescue analgesia  injection diclofenac intravenous given along  with paracetamol infusion if VAS more than 4 and  total doses of intravenous diclofenac will be compared in both groups. We will also noted the post operative pain intensity and SBP, DBP, MAP, HR, SPO2  upto 48 hours at specific interval  time , side effects and total length of hospital stay , compare in both groups. These are compare in both groups.