NCT01444625已完成2 期
Flavanols and Skin Photo Protection: a Double Blind Clinical Trial
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 2
- 主要终点
- Change in Minimal erythema dose
研究概览
简要总结
As flavanols have antioxidants, anti-inflammatory and anti-DNA damaging effects and may increase microcirculation in skin, the purpose of the study is to investigate the chronic effect of flavanol-rich chocolate as an effective strategy to protect against the harmful effect of ultraviolet (UV) radiation.
详细描述
Recent data suggested that chronic ingestion of high flavanols cocoa might be a promising agent for dietary photo protection against UV light. Moreover, flavanols-rich cocoa intake has been shown to increase microcirculation in human skin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Non-smoking women between the ages of 20 and 65 years.
- •Normal skin of type I and II as decried by Fitzpatrick classification.
排除标准
- •Pregnancy and breast feeding.
- •Photo sensibility: history of skin cancers, photosensitizing medication.
- •Sun bed use or sunbathing in the previous 3 months.
- •Use of supplements or natural health products (fish oils, coenzyme Q10, garlic, lycopene, beta carotene).
- •Allergy or intolerance to nuts or chocolate.
结局指标
主要结局
Change in Minimal erythema dose
时间窗: within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption
次要结局
- Change in Skin elasticity(within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption)
- Change in Skin moisture(within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption)
- Change in levels of Vitamin D and polyphenols(within the first 12 weeks of chocolate intake and 3 weeks later after end of chocolate consumption)
研究者
Claudine Blanchet
Coordinator
Laval University
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Role of Flavanols In Cardiovascular Function in Healthy AgingAgingNCT01395277University of Texas at Austin30
撤回
不适用
The Role of Red Flavonoid in PhotoagingPhotoaging of SkinSkin AgingNCT05854628Johns Hopkins University
已完成
3 期
High Total Antioxidant Capacity Products Added to DietHealthyNCT00975728Derming SRL120
招募中
不适用
se of photoliasis and topical antioxidants in the treatment of actinic keratosis and skin cancer field: a randomized controlled trialactinic keratosisRBR-957zf2Faculdade de Medicina de Botucatu - UNESP
招募中
不适用
Adding Polyphenol-rich Pulses to Daily Diet Improves Skin Health by Reshaping the Skin MicrobiomeHealthyNCT06538415University of Florida50