Evaluation of Intraoperative V/Q Mismatch and Compliance Trajectories as Predictors of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- Occurrence of Pulmonary postoperative complications
研究概览
简要总结
Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality. Little is known about the effect of intraoperative VQ mismatch on the occurrence of PPC. In this trial the investigators will evaluate if intraoperative VQ mismatch may predict PPC in a population of patients undergoing major surgery.
详细描述
Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality. Little is known about the effect of intraoperative VQ mismatch on the occurrence of PPC.
PPC are classically considered associated to the occurrence of intraoperative atelectasis, and therefore to the development of a certain amount of shunt, but this concept have been recently questioned.
Recent studies showed indeed that, despite age is one of the main determinants of PPCs, increasing age is not associated to the increase of intraoperative shunt. Shunt therefore may not be the main determinant of PPC.
In this trial the investigators will evaluate if other causes of intraoperative VQ mismatch (e.g. low V/Q, high V/Q, dead space) may predict PPC in a population of patients undergoing major surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-90 years
- •Major elective surgery with general anesthesia
- •Intraoperative cannulation of the radial artery for invasive pressure monitoring
排除标准
- •Thoracic surgery with one lung ventilation
- •Refuse to participate
- •Emergency surgery
结局指标
主要结局
Occurrence of Pulmonary postoperative complications
时间窗: In the first 7 days after surgery
Definition derived from the ESA-ESICM joined taskforce on perioperative outcome measures.
次要结局
- Intraoperative drug administration(During surgery)
- fluid balance(During surgery)
- Intraoperative heart rate(During surgery)
- Intraoperative mechanical measures (pressures)(During surgery)
- V/Q mismatch(During anesthesia)
- Intraoperative arterial pressure(During surgery)
研究者
Savino Spadaro
Principal Investigator
Università degli Studi di Ferrara