ew pharmacotherapeutic treatment options for crack-cocaine dependent people in the Netherlands.

ZonMw0 个研究点开始时间: 2010年12月15日最近更新: 2015年7月10日

试验速览

暂无简介。

•(a) at least 18 years old
•(b) cocaine dependence (DSM-IV) during at least the previous year
•(c) cocaine use on a regular basis (i.e., = 8 days) in the previous month
•(d) administer cocaine primarily by means of basing ('crack')
•(e) able and willing to participate in outpatient psycho-social treatment and associated assessments (control condition), or be able and willing to participate in outpatient psycho-social treatment supplemented with the study medication and associated assessments (experimental condition)
•(f) have provided written informed consent with regard to their assigned study treatment
•In the sub-study with dexamphetamine SR, the minimal duration of cocaine dependency will be five years instead of one year. In addition, patients have to meet one extra inclusion criterion: (g) a history of earlier failed treatments aimed at reducing, or abstaining from, cocaine use ('treatment-refractory').
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•(a) severe medical (e.g., severe renal or kidney insufficiency/failure) or psychiatric problems (e.g. acute psychosis, current major depression, suicidal) as well as comorbid heroin dependence, which constitute a contra-indication for participation
•(b) cardiovascular problems (ECG)
•(c) pregnancy or continued lactation
•(d) indication for treatment with naltrexone, disulfiram, or acamprosate
•(e) anticipated necessity of residential treatment (clinical judgement)
•(f) insufficient command of the Dutch language
•(g) current participation in another addiction treatment trial

发起方