Fibrinolytic treatment of acute respiratory failure due to inflammatory lung injury to assess improvement in alveolar dead space and right ventricular function

St Vincent's Hospital0 个研究点目标入组 12 人开始时间: 2010年11月5日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Patients with acute respiratory failure due to an acute inflammatory insult.
•Requiring positive pressure ventilation via an endo-tracheal tube.
•Impaired oxygenation - arterial partial pressure of oxygen to inspire fraction of oxygen ratio (P/F) <300 mmHg.
•At least one quadrant of pulmonary infiltrate present on CXR.
•Enrolled within 24 hrs of developing all of these criteria.

•Known hypersensitivity to alteplase (t-PA)
•Aspirin in the last week
•Any therapeutic anti-coagulant therapy
•Significant bleeding disorder within the past six months
•Any history of brain or spinal injury including trauma, stroke, transient ischaemic attack, neoplasm, surgery, infection, aneurysm or intracranial bleed.
•Uncontrolled hypertension, systolic blood pressure (BP) >185 mmHg or diastolic BP >110 mmHg.
•Recent (within ten days) prolonged or traumatic cardiopulmonary resuscitation (> 2 minutes), obstetric delivery, organ biopsy, puncture of non-compressible blood vessel (e.g. subclavian vein), major surgery or significant trauma.
•Documented ulcerative gastrointestinal disease during the last three months.
•Arterial aneurysms, arterial/venous malformations.
•Neoplasm with increased bleeding risk.
•Bacterial endocarditis, pericarditis.
•Acute pancreatitis.
•Severe hepatic disease/ dysfunction, including hepatic failure, cirrhosis, portal hypertension (oesophageal varices) or active hepatitis.
•Age <18 or > 75
•Pulmonary haemorrhage in previous 12 months
•Major surgery planned over the next 2 days
•Diabetic haemorrhagic retinopathy or other haemorrhagic ophthalmic conditions.
•Unlikely to survive 24 hours
•Platelet count below 80,000/mm3

发起方

St Vincent's Hospital