Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Post-filter iCa
研究概览
简要总结
It is unclear whether different modes of continuous renal replacement therapy (CRRT) impact post-filter ionized calcium concentrations during regional citrate anticoagulation (RCA) when using calcium-containing replacement fluid.
This prospective, single-center, observational cohort study will screen all patients receiving CRRT for eligibility. General clinical information will be collected before commencing CRRT treatment. Patients will be randomly assigned to either the veno-venous hemofiltration (CVVH) or continuous veno-venous hemodialysis (CVVHD) group and switch to the alternative mode in the subsequent treatment session. Pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent total and ionized calcium will be measured 2 hours after the initiation of CRRT. Electrolyte levels, arterial blood gases, hourly citrate dose, and total citrate dose will be recorded every 6 hours until the end of CRRT. The primary outcome is the difference in ionized calcium concentrations at each site over time between the two modes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years old;
- •Receiving citrate anticoagulation;
- •Obtain Informed consent from patients or next of kin.
排除标准
- •Pregnant or lactating women;
- •Allergic to citrate anticoagulants;
- •Severe liver dysfunction (total bilirubin levels exceeding two times the normal range);
- •Hypoxemia (PaO2 < 60 mmHg);
- •Inadequate tissue perfusion (blood pressure < 90/60 mmHg despite high doses of vasoactive agents);
- •Hyperlactatemia (lactate> 4 mmol/L);
- •Hypernatremia;
- •Estimated length of hospital stay < 48h;
- •Participated in other studies.
结局指标
主要结局
Post-filter iCa
时间窗: 2 hours after the initiation of CRRT
The post-filter ionized calcium concentration
Serum iCa
时间窗: 2 hours after the initiation of CRRT
Serum ionized calcium concentration
Serum Ca2+
时间窗: 2 hours after the initiation of CRRT
Serum total calcium concentration
Effluent Ca2+
时间窗: 2 hours after the initiation of CRRT
Effluent total calcium concentration
次要结局
- Incidence of new-onset metabolic complications(48 hours after the initiation of CRRT)
研究者
Han Chen
Deputy chief physician
Fujian Provincial Hospital