Effect of Lidocaine 5% Patch Supplementation to Intra-articular Bupivacaine Dexmedetomidine After Arthroscopic Knee Surgery Under General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- The total dose of postoperative pethidine consumption
研究概览
简要总结
Surgery of the knee is a very common procedure which can be very painful and sufficient postoperative pain treatment is often problematic. The aim of this work was to study the effects of supplementation of intra-articular bupivacaine dexmedetomidine with lidocaine 5% patch after arthroscopic knee surgery under general anesthesia and its role in improving quality of anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients
- •ASA I & II
- •Aged between 18 to 60 years
- •Weight between 60 to 100 kg
- •Scheduled for elective arthroscopic knee surgery
排除标准
- •patient refusal.
- •history of cardiac disease.
- •impaired renal or hepatic function.
- •hypertension treated with α methyldopa, clonidine, or beta-adrenergic blockers.
- •if they have used opioid analgesics within the previous 24 hr.
- •previous sensitivity to local anesthetics.
研究组 & 干预措施
Group A (control group)
Patients in each received 10 ml 0.5 % bupivacaine and 1µg/kg dexmedetomidine diluted in 10 ml saline injected intra-articularly without lidocaine patch
干预措施: Dexmedetomidine Bupivacaine (Drug)
Group B
Patients in each received 10 ml 0.5 % bupivacaine and 1µg/kg dexmedetomidine diluted in 10 ml saline injected intra-articularly with a patch of lidocaine 5% was applied to the skin
干预措施: Lidocaine 5% patch with Dexmedetomidine Bupivacaine (Drug)
结局指标
主要结局
The total dose of postoperative pethidine consumption
时间窗: 24 hours
The total dose of postoperative pethidine consumption; Pethidine 20 mg was given as rescue analgesia if pain visual analogue visual analogue scale (VAS) ≥4.
次要结局
- First postoperative analgesia request time(24 hours)
- Pain intensity(24 hours)
研究者
Ahmed Said Elgebaly,MD
Assistant professor of Anesthesiology, Surgical Intensive Care
Tanta University