ISRCTN41645723已完成3 期
Optimizing opioid assisted therapy : personalizing treatment using therapeutic drug monitoring and medication management
ational Rehabilitation Center0 个研究点目标入组 141 人开始时间: 2016年8月7日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 141
研究概览
简要总结
2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30956839 protocol (added 05/08/2019) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35953563/ Association of buprenorphine elimination rate constant and opioid use (added 12/08/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/33404141/ (added 12/08/2022)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Male
入选标准
- •1. Males and females aged 18- 64 years
- •2. Diagnosed with current opioid use disorder (ICD-10)
- •3. Current use of street heroin and/or pharmaceutical opioid
- •4. Able to comprehend instructions and consent to the trial participation
- •5. Voluntarily seeking treatment
- •6. Able to be discharged to stable accommodation
排除标准
- •1. Pregnant
- •2. Patients with known hypersensitivity to naloxone or buprenorphine
- •3. Hepatic Impairment (>3 times elevated liver function)
- •4. Any prior suicidal attempt and current active suicide plan
- •5. Involvement in current criminal justice proceedings
- •6. Active uncontrolled severe mental illness or evidence of organic brain disease that is judged by clinical director to compromise patient safety
- •7. Acute and severe respiratory illness
- •8. Paralytic ileus
- •9. Benzodiazepine use (in the past 28 days) in excess of 20 mg daily diazepam equivalent ,2
研究者
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