TCTR20210420006已完成不适用
Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Vernonia cinerea Lozenge in smokers
Thailand Science Research and Innovation (TSRI)0 个研究点目标入组 67 人开始时间: 2021年4月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 67
研究概览
简要总结
In this study, MO leaf extract, VC extract, MO lozenges, and MO+VC lozenges showed strong antioxidant potential and anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines as IL-6 of inflamed human macrophages. Moreover, lozenges containing MO and MO+VC had a strong effect on reducing gingivitis and oral inflammation in smokers.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- All
入选标准
- •Smokers aged between 18 and 65 years, smoked more than 5 cigarettes/day in the past 6 months, diagnosed by a dentist with mild or moderate oral inflammation, and healthy subjects with no allergic history to any ingredient in the lozenges.
排除标准
- •Exclusion criteria included subjects who had a history of disease including diabetes mellitus, cardiovascular, cancer, significant hepatic and renal impairment, neuro-logic and psychiatric disorder, and immunodeficiency, pregnant or breastfeeding, used drugs including antibiotics, anti-inflammatory, anticoagulants, anticonvulsants, immunosuppressive drugs within 6 months before the study visit, severe alcoholism or drug addict, and previous use of anti-inflammation or smoking cessation products within one month.
研究者
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