Cluster Randomised Trial to Compare Effectiveness of the Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) to LLINs Alone for Malaria Prevention in Muleba District, Kagera Region, Tanzania
试验速览
- 阶段
- 4 期
- 入组人数
- 22,300
- 试验地点
- 1
- 主要终点
- Prevalence of malarial infection in children 6 months to 10 years
研究概览
简要总结
The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS.
Findings from this study are expected to inform decision making so that resource utilization can be optimised.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 6 Months 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •resident in selected cluster (village)
排除标准
- •Not resident in selected cluster (village)
结局指标
主要结局
Prevalence of malarial infection in children 6 months to 10 years
时间窗: 9 months post randomisation
次要结局
- Moderate to severe anaemia in children under 5 years(9 months post randomisation)
- Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years(6 months post randomisation)