Efficacy of Bisacodyl Given as Part of a Polyethylene Glycol-based Bowel Preparation Prior to Colonoscopy in Hospitalized Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 600
- 主要终点
- The efficacy of bowel preparation
研究概览
简要总结
The purpose of this study is to compare two regimens of polyethylene glycol(PEG) plus bisacodyl versus PEG alone for bowel preparation in hospitalized patients.
详细描述
Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage without producing significant fluid or electrolyte changes. Thus PEG is now commonly used for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are generally poorly tolerated, especially in hospitalized patients who had comorbidity and restricted ambulation. Recently, a new PEG-based bowel cleansing agents became available. It combines PEG with a high dose of ascorbic acid or bisacodyl. Although many studies reported the efficacy of these combined solution for colonoscopy, but efficacy in hospitalized patients was under-recognized.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Hospitalized patients for colonoscopy
排除标准
- •age under 20 years or over 80 years
- •major psychiatric illness
- •known allergy to PEG
- •serious condition- severe cardiac, renal, or metabolic diseases
- •partial colon resection
- •current acute exacerbation of chronic inflammatory bowel disease
- •functional constipation defined by Rome III diagnostic criteria
结局指标
主要结局
The efficacy of bowel preparation
时间窗: one day (after colonoscopy)
Ottawa scale
次要结局
- Patient's compliance and acceptability(one day (after injestion of preparation solution))
- Patient's compliance and acceptability (2)(one day (after injestion of preparation solution))
- Patient's compliance and acceptability (3)(one day (after colonoscopy))
研究者
Dong Il Park, M.D, Ph.D.
Associate professor, Department of Internal Medicine
Kangbuk Samsung Hospital
