NCT02957188已完成不适用
Metabolism of Uniformly Labelled 13C Eicosapentaenoic Acid and 13C Arachidonic Acid During Healthy Aging
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 主要终点
- Kinetics of 13C-EPA and 13C-AA
研究概览
简要总结
The purpose of this study is to determine the kinetics of 13C-eicosapentaenoic acid (EPA) and 13C-arachidonic acid (AA) in young and older participants
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •six young (18-30 y old) and six older (≥ 70 y old)
- •healthy non medicated participants.
排除标准
- •malnutrition (assessed from blood albumin, haemoglobin and lipids), -
- •participants taking an EPA+DHA supplements or consuming more than 2 fish meals per week,
- •severe gastro-intestinal problems,
- •medication for diabetes,
- •thyroid disease,
- •renal failure,
- •psychiatric difficulties or depression,
- •cardiovascular disease,
- •glucose intolerance (>8 mmol/L in fasted samples)
- •chronic immune condition or inflammation (CRP > 10 mg/l, white cell count),
- •recent major surgery or cardiac event,
- •dementia,
- •ongoing or past severe drug or alcohol abuse,
- •ongoing or past intensive physical training.
结局指标
主要结局
Kinetics of 13C-EPA and 13C-AA
时间窗: Plasma incorporation of 13C-EPA or 13C-AA was measured from the area under the curve in young and older participants over 28 days post-dose
次要结局
未报告次要终点
研究者
Mélanie Plourde
Professor
Université de Sherbrooke
相似试验
已完成
不适用
Bioavailability of EPA/DHA in of Ruby-O and Krill OilBioavailabilityNCT05438173Midwest Center for Metabolic and Cardiovascular Research28
已完成
不适用
Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal CancerUlcerative ColitisNCT02069561IRCCS Azienda Ospedaliero-Universitaria di Bologna25
已完成
1 期
Study of the Absorption, Metabolism, and Route of Elimination of a Novel Class of Anti-HIV 1 Drugs (BMS-955176) in Humans.HIV InfectionsNCT02206711ViiV Healthcare21
招募中
不适用
Evaluation of eicosapentaenoic acid (EPA) for preventing the progression of coronary atherosclerosis and revascularization in patients with dyslipidemia who underwent percutaneous coronary intervention (PCI)Coronary artery disease with dyslipidemiaJPRN-UMIN000003947Kurashiki central Hospital200
已完成
1 期
Metabolism and Pharmacokinetics of [14C]-BIIL 284 BS in Healthy VolunteersHealthyNCT02266550Boehringer Ingelheim6