A Prospective Pilot Study to Evaluate a New Marker of Ischemia in Chest Pain Triage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- blood sample : dosage of CD26
研究概览
简要总结
A Single-center prospective pilot study enrolling chest pain patients. CD 26 measurement will be performed and compared to troponin µs for early triage of these patients. This novel biomarker of myocardial ischemia (CD26) will be measured at the time of first medical contact (T0) and after 30 min simultaneously o troponin Ic.
All patients aged over 18 years with chest pain which may be related to acute coronary syndrome requiring pre hospital medical contact through the Emergency Medical Service.
详细描述
First objectives: demonstrating the early positivity of CD26 compared to ultra-sensitive troponin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subject with compatible symptoms with an acute coronary syndrome, for at least 15 minutes and not older than 3 hours (eg discomfort, tightness or chest pain, pain radiating to the left arm or two arms, pain in the jaw, pain in the back / neck / stomach, breathlessness , cold sweats, nausea / vomiting , dizziness )
- •Man or woman,
- •Patient Did not receive heparin or low molecular weight heparin (LMWH ) before the initial blood sample ,
- •Patient Agreeing to participate in the study and who signed an informed consent
排除标准
- •Minor or major patient trust
- •Patient Not having signed informed consent (refusal , physical or mental disability ... )
- •Patient Who received anticoagulation before carrying blood samples
- •Patient With a progressive septic processes , neoplasia undergoing treatment, dialyzed kidney failure, a history of surgery or coronary angioplasty less than six months.
- •Transplanted heart, renal or hepatic
- •heart attack
- •Subject Whose symptoms clearly eliminates acute coronary syndrome ( penetrating trauma, traumatic injury by crushing ... )
- •Patient Died between the time of inclusion and arrival in the cardiology intensive care ( SIC )
- •Patient Withdrawing consent under study
结局指标
主要结局
blood sample : dosage of CD26
时间窗: 12 MONTHS
demonstrating the early positivity of CD26 compared to ultra-sensitive troponin.
blood sample: dosage of the copeptin
时间窗: 12 months
blood sample: dosage of troponin
时间窗: 12 months
blood sample : dosage of IMA
时间窗: 12 months
IMA (Albumin modified by the ischaemia)
blood sample: dosage of adenosin
时间窗: 12months
次要结局
未报告次要终点