Computational Analysis of Spoken Language in Mania
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Acoustic Differences
研究概览
简要总结
This research is being done to find if there are changes with voice and speech during episodes of mania.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Provision of informed consent before any study procedures are performed
- •English speaker
- •Documented clinical diagnosis for Bipolar I Disorder
- •Undergoing hospitalization, or boarding in the Emergency Department, for mania as determined by primary clinical staff
排除标准
- •Positive urine drug screen for amphetamines or cocaine.
- •Expressing paranoid delusions regarding electronic surveillance.
- •Documented clinical diagnosis of developmental delay.
- •Currently involuntarily hospitalized.
- •Deemed at risk for aggression.
- •Failure to comprehend study objectives via comprehension questionnaire.
- •Individuals who have a guardian and are unable to consent for themselves.
- •Current communicable disease requiring isolation.
研究组 & 干预措施
Recording Session During Hospitalization
While inpatient, participants will undergo a research interview with recorded audio.
干预措施: Research interview (Behavioral)
结局指标
主要结局
Acoustic Differences
时间窗: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment
The raw audio data will be analyzed for change in pitch, variability of rhythm, and response time.
Syntactical Differences
时间窗: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment
Audio data will be transcribed using voice to text software and then analyzed for syntactical elements of speech including sentence structure and grammar.
Semantic Differences
时间窗: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment
Transcribed audio data will be analyzed for changes in verbosity, lexical diversity, and coherence on a sentence and paragraph level.
次要结局
未报告次要终点