NCT01573988终止不适用
Behavioural and Metabolic Consequences of Increasing Eating Frequency
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Ghrelin plasmatic concentration
研究概览
简要总结
In this study, the investigators are interested in assessing the effects of the isocaloric increase of eating frequency on appetite and metabolism. How the consumption of an isocaloric breakfast in four intakes vs. one can modify satiety and appetite control in lean and obese subjects through :
- the physiological consequences : difference in postprandial kinetics of glucose, non esterified fatty acid, triglyceride, the secretion of satiety gut hormone (insulin, ghrelin, leptin and cholescystokinine (CCK), peptide YY (PYY), glucagon-like peptide-1 (GLP-1), nutrients oxidative fate and plasmatic oxidative stress (Malondialdehyde (MDA), glutathion, lipid hydroperoxides)
- eating behavior during an ad libitum buffet test meal
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •No smokers
- •BMI 20 to 35 kg/m2
- •Moderate physical activity
- •Safety during medical consultation
- •Feeding behavioural phenotype (Dutch Eating Questionnaire, Three Eating Factor Questionnaire)
排除标准
- •Medical history which may affect glucose metabolism (diabetes, renal or hepatic failure, thyroid dysfunction, Cushing syndrome, acromegaly...)
- •Medical history which affect nutrient absorption (gastro-intestinal and pancreatic disease, gastrectomy, colectomy...)
- •Drug use in the last two months that could affect glucose metabolism (steroids, topical gastric preparation, anorectic drugs...)
- •Eating disorders
- •Claustrophobic subjects
结局指标
主要结局
Ghrelin plasmatic concentration
时间窗: 240 minutes after breakfast beginning (just before the lunch)
次要结局
- Satiety through food intakes (quantitative) at the ad libitum buffet test meal(Since the beginning of the buffet test meal (240 minutes after breakfast beginning) to the end of the meal (at the latest 270 minutes after breakfast beginning).)
- Satiety through visual analogue scale(240 minutes after breakfast beginning (just before the lunch))
- Plasma metabolite concentrations (glycaemia, non esterified fatty acid,(kinetics during 430 minutes)
- Endocrine concentrations (insulin, ghrelin, GLP-1, PYY, leptin, C-peptide)(kinetics during 430 minutes)
- Plasma markers of oxidative stress (MDA, gluthation, lipid hydroxide)(kinetics during 430 minutes)
- Lipid oxidation(kinetics during 430 minutes)
- Eating behaviour at the buffet test meal by video recording (food choice, nutritional composition of the meal , kinetics of nutrient intake, meal structure, lunch duration)(during the buffet test meal (max : 30 minutes))
研究者
研究点 (2)
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