Gene Expression in Isolates of Group A Streptococci Recovered From Patients Who Are Carriers
概览
- 阶段
- 不适用
- 干预措施
- Identifying group A strep carriers
- 疾病 / 适应症
- Streptococcal Pharyngitis
- 发起方
- University of Wisconsin, Madison
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Identifying children who are pharyngeal carriers of Group A streptococcus
- 状态
- 招募中
- 最后更新
- 2个月前
概览
简要总结
The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.
详细描述
The overall objective of this investigation is to understand the differences in Group A streptococci in children who are acutely infected from those who are carriers. The hypothesis is that when in the carrier state, GAS exhibits unique transcriptional profiles that differ from those of the acute infection state. The investigators expect transcriptional profiles of GAS to provide important information regarding the changes the organism undergoes when transitioning between acute infection and carriage. The specific aims of this study are: 1. To collect longitudinal participant-samples from acute and carriage phases of GAS infection and compare transcriptomic profiles and whole genome sequences of GAS recovered from acute and carrier pharyngeal swabs obtained from the same participants. 2. To evaluate how identified differentially expressed genes, or observed genetic polymorphisms, influence GAS models of bacterial colonization and pathogenesis. To do this, the investigators will to identify 12 children with acute pharyngitis due to Group A streptococcus (GAS) who are pharyngeal carriers of GAS. Thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between October and May will have a positive culture or rapid antigen detection test for GAS. Approximately 8-10% of these children with pharyngitis and a positive culture or rapid antigen detection test (RADT) for GAS will be carriers. Therefore,180 participants will need to be enrolled.
研究者
入排标准
入选标准
- •Children ages 5-15 years
- •Positive rapid antigen detection test for group A streptococcus
- •Parent or legal guardian present and able to provide consent
- •Provider prescribes treatment with a beta lactam antibiotic
- •English speaking
排除标准
- •Unable to take beta lactam antibiotics
- •Other concurrent bacterial infection, i.e., pneumonia
研究组 & 干预措施
Rapid Strep Positive
Children will be eligible for this study if they are ages 5 to 15 years and have been diagnosed to have acute pharyngitis caused by GAS with a positive Rapid Antigen Detection Test (RADT).
干预措施: Identifying group A strep carriers
结局指标
主要结局
Identifying children who are pharyngeal carriers of Group A streptococcus
时间窗: 2 weeks
The specific aim of this study is to identify 30 children with acute pharyngitis due to Group A streptococcus (GAS) and 30 children who are pharyngeal carriers of GAS. Thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between October and May will have a positive culture or rapid antigen detection test for GAS. Approximately 10-15% of these children with pharyngitis and a positive culture or rapid antigen detection test (RADT) for GAS will be carriers