Evaluation of Regenerative Potential of Pulp in Necrotic Mature teeth using Chitosan-Loaded Triple Antibiotic paste: A Randomised clinical trial.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To evaluate the regenerative potential of pulp in necrotic mature teeth with and without chitosan loaded triple antibiotic paste.
研究概览
简要总结
The regenerative endodontic procedure represents a transformative approach to preserving dental pulp vitality and restoring damaged infected teeth. According to the literature, very few clinical studies are reported which evaluate the clinical outcome using chitosan-loaded triple antibiotic.
Chitosan, a biocompatible and biodegradable polymer has gained attention as an ideal carrier for drug delivery. This study aims to assess the clinical outcome of regenerative endodontic procedures in mature necrotic teeth with and without chitosan-loaded triple antibiotic paste.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 30.00 Year(s)（—）
- 性别
- All
入选标准
- •patients in the age range of 18–30 years without systematic disease/allergic reactions
- •Nonvital single- rooted teeth (anterior or premolars) encasing 1 root canal with mature roots (closed apices) and a periapical lesion score ≥3 according to Ostravik et al.
- •Score 1: Normal periapical structure Score 2: Small changes in bone structure Score 3: Changes in bone structure with mineral loss Score 4: Periodontitis with well-defined radiolucency Score 5: Severe periodontitis with exacerbating factors.
排除标准
- •Medically compromised patients (with immunosuppressive/systemic diseases, patients on medications).
- •periodontologically compromised teeth.
- •Endodontically treated teeth
- •Teeth with periapical lesions more than 5 mm in diameter.
- •Patients who refuse to participate.
- •Anatomical variations leading to inability to reach the full working length.
结局指标
主要结局
To evaluate the regenerative potential of pulp in necrotic mature teeth with and without chitosan loaded triple antibiotic paste.
时间窗: The outcome will be assessed at 6months and 1 year .
次要结局
- Vitality of tooth(the vitality of the tooth will be assessed with electric pulp testing device after 6 months and 1 year of the treatment)
研究者
Dr Asiya Sameer Mujawar
M.A.Rangoonwala college of dental science and research centre