Detection and Characteristic of Whipple Diseases in the Great Britany
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 267
- 试验地点
- 8
- 主要终点
- Number of patients diagnosed as whipple's disease
研究概览
简要总结
Whipple's disease is a chronic systemic infection caused by ubiquitous bacterium Tropheryma wipplei on a genetic predisposition which should be considered in patients with recurrent episodes of seronegative arthritis, erosive or not, or inflammatory low back pain, chronic diarrhea, persistent fever, unexplained neurological signs, uveitis, endocarditis, and epithelioid granuloma.
Laboratory tests may show malabsorption, erythrocyte sedimentation rate and C-reactive protein elevation, anemia, thrombocytosis, eosinophilia and lymphopenia.
None of theses findings is specific and most patients have arthritis or low back pain mimicking rheumatoid arthritis and spondyloarthritis.
As the disease is rare, chance for positive polymerase chain reaction testing for Tropheryma whipplei is low in this context.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient with at least a screening test for Whipple'disease
- •participation agreement,
排除标准
- •No test for Whipple'disease
结局指标
主要结局
Number of patients diagnosed as whipple's disease
时间窗: Day 0 ( Date of diagnostic)
Diagnosis of Whipple's disease based on * at least one suggestive clinical finding * at least one test detecting T. Whipplei * diagnosis made by a specialist * a dramatic and persistent response to antibiotic therapy * Hydroxychloroquine 200mgx2 plus Doxycycline 100mgx2 * or trimethoprim/sulfamethoxazole 800/160mg x2
次要结局
- Number of test performed in each centre(Day 0 (Date of diagnostic))