The Effect of Bovine Colostrum Supplementation in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- change from baseline in lean tissue mass at 8 weeks
研究概览
简要总结
Bovine colostrum is the initial milk secreted by cows during the first day after calving. Colostrum is high in protein and contains a number of substances that have potential to be beneficial for the immune system. Preliminary studies about effects of colostrum supplementation show its potential for increasing human exercise performance; however, more evidence across the lifespan is required to confirm effects and to understand mechanisms of action. The objectives are to determine the effect of 8 weeks of bovine colostrum supplementation, compared to whey protein supplementation on the following dependent variables in men and women 50 years and older while participating in a resistance-training program:
- muscle mass
- strength
- blood levels of growth factors and markers of inflammation
- urine levels of muscle and bone catabolic markers
- tests of cognitive ability It is hypothesized that bovine colostrum supplementation will result in greater increases in muscle mass, strength, blood IGF-1 levels (an anabolic hormone), and cognitive ability, and greater reductions in inflammation, and markers of muscle and bone catabolism, compared to placebo.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men or women 50 y or older
排除标准
- •Milk allergies
- •Contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire
结局指标
主要结局
change from baseline in lean tissue mass at 8 weeks
时间窗: baseline and 8 weeks
Lean tissue mass assessed by dual energy x-ray absorptiometry
Change from baseline in Upper body strength at 8 weeks
时间窗: baseline and 8 weeks
Bench Press Strength
Change from baseline in Lower body strength at 8 weeks
时间窗: baseline and 8 weeks
Leg press strength
次要结局
- Change from baseline in lower body muscle thickness at 8 weeks(baseline and 8 weeks)
- Change from baseline in muscle catabolism at 8 weeks(baseline and 8 weeks)
- Change from baseline in Insulin like growth factor-1 at 8 weeks(baseline and 8 weeks)
- Change from baseline in upper body muscle thickness at 8 weeks(baseline and 8 weeks)
- Change from baseline in bone catabolism at 8 weeks(Baseline and 8 weeks)
- Number of Participants with Adverse Events as a Measure of Safety and Number of Participants with Adverse Events as a Measure of Safety and Tolerability(continuously throughout 8 weeks)
- Change from baseline in inflammation at 8 weeks(baseline and 8 weeks)
- Change from baseline in cognitive ability at 8 weeks(baseline and 8 weeks)
研究者
Phil Chilibeck
Ph.D.
University of Saskatchewan